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Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4.
Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 (SH3)‐mediatedExpand
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TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.
We describe a new signal mediator of NF-kappaB activation, TANK, that acts in a pathway common to two surface receptors CD40 and TNFR II. TRAF family members interact directly with these receptors.Expand
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Involvement of CRAF1, a relative of TRAF, in CD40 signaling
CD40 is a receptor on the surface of B lymphocytes, the activation of which leads to B cell survival, growth, and differentiation. A yeast two-hybrid screen identified a gene, CRAF1, encoding aExpand
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Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
TRAF3 was found as a protein that binds to the cytoplasmic tail of CD40 but is part of a family of proteins with common structure and activity. To clarify the physiological roles of TRAF3, weExpand
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Localization of the Major NF-κB-activating Site and the Sole TRAF3 Binding Site of LMP-1 Defines Two Distinct Signaling Motifs*
The TRAF3 molecule interacts with the cytoplasmic carboxyl terminus (COOH terminus) of the Epstein-Barr virus-encoded oncogene LMP-1. NF-κB activation is a downstream signaling event of tumorExpand
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Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.
Bruton's tyrosine kinase (Btk) is a recently described B-cell-specific tyrosine kinase. Mutations in this gene lead to human X chromosome-linked agammaglobulinemia and murine X-linkedExpand
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Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
To study the binding specificity of Src homology 3 (SH3) domains, we have screened a mouse embryonic expression library for peptide fragments that interact with them. Several clones were identifiedExpand
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A Nuclear Tyrosine Kinase Becomes a Cytoplasmic Oncogene a
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The design and prediction of biological characteristics of ICOS-Linker-Ig
Objective To construct the expressed recombinant ICOS-Linker-Ig and predict the rationality and feasibility of the linker.Methods Human ICOS and IgG Fc fragment were produced by polymerase chainExpand