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Fast and flexible simulation of DNA sequence data.
Simulation of genomic sequences under the coalescent with recombination has conventionally been impractical for regions beyond tens of megabases. This work presents an algorithm, implemented as the… Expand
A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development.
The Drosophila gene groucho (gro) encodes a transcriptional corepressor that has critical roles in many development processes. In an effort to illuminate the mechanism of Gro-mediated repression, we… Expand
Groucho/TLE family proteins and transcriptional repression.
The Drosophila Groucho (Gro) protein is the prototype for a large family of corepressors, examples of which are found in most metazoans. This family includes the human transducin-like Enhancer of… Expand
Meta-analysis identifies common variants associated with body mass index in East Asians
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We… Expand
Ballistic-diffusive heat-conduction equations.
- G. Chen
- Physics, Medicine
- Physical review letters
- 12 March 2001
We present new heat-conduction equations, named ballistic-diffusive equations, which are derived from the Boltzmann equation. We show that the new equations are a better approximation than the… Expand
The landscape of recombination in African Americans
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a… Expand
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of… Expand
A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the… Expand
A Role for Groucho Tetramerization in Transcriptional Repression
ABSTRACT The Drosophila Groucho (Gro) protein is a corepressor required by a number of DNA-binding transcriptional repressors. Comparison of Gro with its homologues in other eukaryotic organisms… Expand
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast… Expand