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Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
TLDR
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population
TLDR
This study in Indian subjects replicates the strong association of TCF7L2 variants with type 2 diabetes in other populations and provides evidence that variations in TCF 7L2 may play a crucial role in the pathogenesis of type 1 diabetes by influencing both insulin secretion and insulin resistance.
The genetic architecture of type 2 diabetes
TLDR
Large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes, but most fell within regions previously identified by genome-wide association studies.
Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians
TLDR
This study replicates the association of well-established common variants with type 2 diabetes in Indians and shows larger effect size for most of them than those reported in Europeans.
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
TLDR
FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans.
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
TLDR
Examination of genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolicBlood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs supports the notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.
Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
TLDR
Irrespective of the aetiology, mutations in the PRSS1 gene are not associated with chronic pancreatitis, including HP, and the N34S mutation in the SPINK1 gene shows a significant correlation in these patients.
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians
TLDR
This study replicates the strong association of FTO variants with type 2 diabetes and similar to the study in North Indians Sikhs, shows that this association may not be entirely mediated through BMI.
Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis
TLDR
A comprehensive meta-analysis of various studies from different ethnic populations confirms the significant association of MC4R polymorphism with risk of obesity.
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