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Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have beenExpand
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Evaluation of Dopaminergic Presynaptic Integrity: 6-[18F]Fluoro-L-Dopa Versus 6-[18F]Fluoro-L-m-Tyrosine
The effectiveness of 6-[18F]fluoro-L-m-tyrosine (6FMT) to evaluate dopamine presynaptic integrity was compared to that of 6-[18F]fluoro-L-dopa (6FDOPA) in vivo by positron emission tomography (PET).Expand
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Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase.
UNLABELLED Graphical methods to analyze tracer time-course data allow reliable quantitation of the rate of incorporation of tracer from plasma into a "trapped" kinetic component, even when theExpand
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Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects.
UNLABELLED The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y. METHODS The scan-to-scan variation of severalExpand
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Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects.
UNLABELLED The reproducibility of [11C]SCH 23390 in PET was studied in 10 normal human subjects. METHODS The scan-to-scan variation of several measures used in PET data analysis, including theExpand
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The transport of L‐6‐fluorodopa and its metabolites from blood to cerebrospinal fluid and brain
The transport of L‐6‐fluorodopa and its major metabolites from the blood to the brain, cerebrospinal fluid (CSF), and muscle was studied in carbidopa‐pretreated cynomolgus monkeys. A bolusExpand
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6‐[18F]fluoro‐L‐DOPA PET studies of the turnover of dopamine in MPTP‐induced parkinsonism in monkeys
This report describes a method to assess, in vivo, the turnover of dopamine (DA) and describes its application to the evaluation of DA function in normal monkeys and monkeys withExpand
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Analysis of Four Dopaminergic Tracers Kinetics Using Two Different Tissue Input Function Methods
The integrity of the dopaminergic system can be studied using positron emission tomography. The presynaptic tracers [11C]-methylphenidate and [11C]dihydrotetrabenazine (DTBZ) are used to investigateExpand
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Quantitative comparison of three- and two-dimensional PET with human brain studies.
UNLABELLED The aim of this study was to test the quantitation accuracy of three-dimensional PET in brain scanning. METHODS Three-dimensional data from 11 human subjects were tested usingExpand
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Routine determination of [18F]-L-6-fluorodopa and its metabolites in blood plasma is essential for accurate positron emission tomography studies.
A batch-contact alumina-extraction method has been used to separate [18F]-L-6-fluorodopa (FD) from its principal metabolite, 3-O-methyl-[18F]-6-fluorodopa (3-OMe-FD), in arterial blood plasma samplesExpand
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