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Betula pendula leaves: polyphenolic characterization and potential innovative use in skin whitening products.
TLDR
Results showed that BE was capable to inhibit dose-dependently l-DOPA oxidation catalyzed by tyrosinase, and the usefulness of birch leaves extracts in cosmetic and pharmaceutical industries for their skin-whitening and antioxidant effects is suggested. Expand
HER2 status in advanced gastric carcinoma: A retrospective multicentric analysis from Sicily
TLDR
Investigations performed jointly by pathologists and oncologists within the geographical area of the present study should confirm that the association of trastuzumab with chemotherapy results in an improvement of survival in patients with AGC. Expand
Phytochemical screening of Artemisia arborescens L. by means of advanced chromatographic techniques for identification of health-promoting compounds.
TLDR
A detailed fingerprint of the essential oil from A. arborescens aerial parts was obtained, highlighting an abundant presence of chamazulene followed by camphor, β-thujone, myrcene, and α-pinene, while the anti-angiogenic activity was investigated in the dichloromethane extract. Expand
Betula pendula Roth leaves: gastroprotective effects of an HPLC-fingerprinted methanolic extract
TLDR
Oral pretreatment of rats with BLE significantly reduced the incidence of gastric lesions induced by ethanol administration as compared with misoprostol and inhibited the increase in malondialdehyde (MDA) and prevented depletion of total sulhydryl and non-protein sulHydryl groups in rat stomach homogenate when compared with ethanol group. Expand
Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors.
TLDR
Experimental and computational structural studies were performed in order to clarify the binding mode of the derivative 2d and reveal that compounds 2 a-c and 10b act as non-competitive inhibitors while the most active inhibitor 2d is a mixed-type inhibitor. Expand
Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
TLDR
Results indicated 1 as a new antiangiogenic compound inhibiting the interaction between VEGF-A or PlGF and their receptor VEGRF-1. Expand
Anti-angiogenic activity and phytochemical screening of fruit fractions from Vitex agnus castus
TLDR
Preliminary results highlighted a potential anti-angiogenic activity of V. agnus castus fruits in zebrafish embryos treated with chloroform or ethyl acetates. Expand
Searching for indole derivatives as potential mushroom tyrosinase inhibitors
TLDR
The idea was to screen the “in house” database to select suitable lead compounds for the discovery of potential drug-inhibiting enzyme, and it was demonstrated that compounds containing 4-fluorobenzyl moiety at N − 1 position of indole system showed the best activity. Expand
Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
TLDR
A combination of crystallographic and docking studies on two different tyrosinases, that from Bacillus megaterium (TyBm) and that from a mushroom (TyM), has contributed to increasing knowledge about their structural information and translating that information to the most druggable human Ty (TyH) isozyme. Expand
Anti-angiogenic activity of Entada africana root
TLDR
Results obtained in this study suggest that the anti-angiogenic effects of E. africana root may account for its use in inflammatory diseases and other related pathological conditions. Expand
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