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Heparin-induced thrombocytopenia.
TLDR
The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II, the most frequent and dangerous side-effect of heparin therapy.
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Pathophysiology of heparin-induced thrombocytopenia. Clinical and diagnostic implications--a review.
TLDR
Past experience with various anticoagulant treatments is reviewed with a focus on the recent successes of thrombin inhibitors and platelet GPIIb/IIIa inhibitors to combat the platelet activation and severe thrombotic episodes associated with HIT.
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Plasma markers of endothelial dysfunction in pulmonary hypertension.
TLDR
The data seem to suggest a need for newer agents that are able to increase the antithrombotic endothelial function in patients with severe pulmonary hypertension and the need for chronic anticoagulation believed to increase survival in these patients.
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Nitric oxide derivatives and soluble plasma selectins in patients with myeloproliferative neoplasms.
TLDR
HU-mediated increase of NOX levels could represent an additional antithrombotic mechanism of this drug and demonstrate that ET and PV are characterised by an altered pattern of soluble selectins and NOX.
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Endothelial dysfunction in haemophilia patients
TLDR
An endothelial dysfunction with impaired FMD and t‐PA release in haemophilia patients is found, usually associated with cardiovascular risk factors, and other pathogenic mechanisms are likely to be involved in this endothelial damage.
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Defining the Thrombotic Risk in Patients with Myeloproliferative Neoplasms
TLDR
The identification of plasma markers translating the hemostatic imbalance in patients with PV and ET would be extremely helpful in order to define the subgroup of patients with a significant clinical risk of thrombosis.
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Platelet count, anti-heparin/platelet factor 4 antibodies and tissue factor pathway inhibitor plasma antigen level in chronic dialysis.
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Circulating microparticles of glial origin and tissue factor bearing in high-grade glioma: a potential prothrombotic role.
TLDR
The numbers of glial-derived and/or TF-bearing MPs were high in GBM patients both before and even more after the neoplasm was treated, especially in patients with subtotal resection likely according to disease progression.
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Coagulation Activation in Children with Sickle Cell Disease Is Associated with Cerebral Small Vessel Vasculopathy
TLDR
SS-Sβ° disease is associated with extensive activation of the coagulation system at steady state since young age and ADAMTS-13 and t-PA:Ag are involved in the development of cerebral silent infarcts.
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Effect of Bosentan on Plasma Markers of Endothelial Cell Activity in Patients with Secondary Pulmonary Hypertension Related to Connective Tissue Diseases
TLDR
Treatment with bosentan for 3 months induced a beneficial effect by restoring endothelial function through a decrease in the markers of endothelial cell activity, leading to stabilization or improvement of severe PAH.
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