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Peptides That Mimic the Amino-Terminal End of the Rabies Virus Phosphoprotein Have Antiviral Activity
Peptides mimicking various lengths of the amino-terminal end of P have been evaluated for their capacity to inhibit rabies virus infection of BHK-21-T7 cells and of two derivatives of the neuronal SK-N-SH cell line. Expand
Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France
Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Expand
Energy Efficiency Evaluation of a Plug-in Hybrid Vehicle under European Procedure, Worldwide Harmonized Procedure and Actual Use
A two-fold approach carried out in collaboration between IFPEN and the French ADEME with the aim to evaluate a Plug-in Hybrid vehicle according to its conditions of use, using the PHEV simulation tool and software principles. Expand
Changes in Diversification Patterns and Signatures of Selection during the Evolution of Murinae-Associated Hantaviruses
This study focused on Murinae-associated hantaviruses using sequences available in GenBank and conducted several complementary phylogenetic inferences, supporting the assumption that RNA virus molecular variations were under strong evolutionary constraints and revealing changes in patterns of diversification during the evolutionary history of hantviruses. Expand
Estimation of main diversification time-points of hantaviruses using phylogenetic analyses of complete genomes.
The results support an earlier developed hypothesis of co-speciation of known hantaviruses with their respective mammal hosts and hence a common ancestor for all hantviruses carried by placental mammals. Expand
Phage Display of Combinatorial Peptide Libraries: Application to Antiviral Research
A review of the use of phage display in antiviral research and drug discovery is presented, with a discussion of optimized strategies combining the strong screening potential of this technique with complementary rational approaches for identification of the best target. Expand
Dermaseptins as potential antirabies compounds.
This study highlights the potential interest of dermaseptins as non-expansive alternatives to rabies immunoglobulins for the treatment of rabies that continues to claim about 60,000 human lives per year worldwide, almost exclusively in developing countries. Expand
Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean.
- C. Filippone, G. Castel, +13 authors N. Tordo
- Biology, Medicine
- The Journal of general virology
- 1 May 2016
Sera from 642 mammals from La Réunion and Mayotte islands were screened for the presence of hantaviruses by molecular analysis, and a new variant of Thailand virus was discovered in Rattus rattus from Mayotte island. Expand
Phylogeography of Puumala orthohantavirus in Europe
This study attempts to reconstruct the phylogeographical spread of modern PUUV throughout Europe during the last postglacial period in the light of an upgraded dataset of complete PUUV small (S) segment sequences and by using most recent computational approaches. Expand
Experimental infections of wild bank voles (Myodes glareolus) from nephropatia epidemica endemic and non-endemic regions revealed slight differences in Puumala virological course and immunological…
The results suggest the existence of regional variations in the sensitivity of bank voles that could contribute to the apparent absence of PUUV circulation among voles and the absence of NE in the non-endemic region. Expand