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Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems
The objectives of this study were to validate new experimental techniques used to measure the log P of protonated drugs, and to investigate the inter- and intramolecular forces influencing theExpand
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Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant.
Human alpha1-acid glycoprotein (AAG) is a mixture of at least two genetic variants: the A variant and the F1 and/or S variant or variants, which are encoded by two different genes. In a continuationExpand
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On the complexation of quercetin with methyl-β-cyclodextrin: photostability and antioxidant studies
Quercetin, a plant-derived flavonoid, has been extensively investigated for a wide range of potential health benefits linked to its antioxidant properties. Unfortunately the topical administration ofExpand
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Molecular Factors Influencing Retention on Immobilized Artificial Membranes (IAM) Compared to Partitioning in Liposomes and n-Octanol
AbstractPurpose. To assess the effect of molecular factors influencing retention on immobilized artificial membrane (IAM) high-performance liquid chromatography columns compared to liposomalExpand
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Viability assessment of bacteria in mixed populations using flow cytometry *
In microbiology cells are called viable when they can be shown to proliferate. Due to long lag phases and the cells' sensitivity to the conditions around them, this definition presents problems whenExpand
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Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine
Reference LEPA-ARTICLE-2001-013doi:10.1002/1522-2675(20010228)84:2 3.0.CO;2-4 Record created on 2005-11-07, modified on 2017-05-12
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Lipophilicity Profiles of Ampholytes.
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In silico design, photostability and biological properties of the complex resveratrol/hydroxypropyl-β-cyclodextrin
The topical administration of trans-resveratrol is limited because of its fast degradation upon UV irradiation. As assessed in the literature, cyclodextrins are able to protect the guest moleculeExpand
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Lipophilicity Behaviour of the Zwitterionic Antihistamine Cetirizine in Phosphatidylcholine Liposomes/Water Systems
AbstractPurpose. The partitioning of cetirizine in a phosphatidylcholine liposomes/water system was compared with that of hydroxyzine and acrivastine to gain insight into the mechanisms ofExpand
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