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Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the…
The data further verify the neuromuscular blocking properties of CW002, including rapid reversal by L-cysteine of 100% NMB under several circumstances, and a notable lack of autonomic or circulatory effects provided added proof of safety and efficacy.
Survival Efficacy of the PEGylated G-CSFs Maxy-G34 and Neulasta in a Mouse Model of Lethal H-ARS, and Residual Bone Marrow Damage in Treated Survivors
Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy- G34, as well as Neulasta, as MCM against radiation.
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor…
Compound 7 (RG 12553), with a Ki value of 0.1 nM, has higher affinity than the natural agonist LTD4 and is one of the most potent LTD4 antagonists reported.
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity.
Compound 27 [RG 12525, 5-[[2-[[4-(2-quinolinylmethoxy)phenoxy]- methyl]phenyl]methyl]-1H-tetrazole] represents the best combination of in vitro and in vivo biological activity in this series and has been selected for further evaluation in clinical studies of asthma.
Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs.
The effect of calcium antagonists on allergic pulmonary distress in actively sensitized rats
The present data suggest that the calcium antagonists verapamil, nifedipine and diltiazem, can attenuate APD and therefore might be clinically active agents in the treatment of allergic asthma.
Relationship between progesterone suppression and pregnancy in rats
- G. Carnathan, L. Metcalf, R. Cochrane, E. F. Nutting, D. L. Black
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 1 May 1987
A statistical analysis of the data suggests that, regardless of the mechanism of action of a particular luteolytic agent, a treatment‐induced depression of serum progesterone to concentrations less than 45% of that of the controls on day 11 of pregnancy is incompatible with pregnancy maintenance.
Narcotic blockade, length of addiction and persistence of etonitazene consumption in rats
Animals with a greater history of previous drug exposure developed ETZ preferences more rapidly than did relatively drug-naive animals, and animals with the greatest history of prior addiction continued to drink large quantities of ETZ, despite pretreatment with relatively large doses of naloxone.
Cardiopulmonary effects of celiprolol and bisoprolol in serotonin-infused cats.
Morphine-based secondary reinforcement: Effects of different doses of naloxone
The effects of different doses of naloxone on morphine-based secondary reinforcement were studied in rats, and the secondary reinforcement tests reliably predicted behavior on a subsequent test for acquisition of morphine-seeking behavior.