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The Saccharomyces cerevisiae Lipin Homolog Is a Mg2+-dependent Phosphatidate Phosphatase Enzyme*♦
The Saccharomyces cerevisiae PAH1-encoded Mg2+-dependent PA phosphatase shows homology to mammalian lipin, a fat-regulating protein whose molecular function is unknown. Expand
Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae
Genome-wide genetic analysis indicates coordinate regulation between glycerolipid metabolism and a broad spectrum of metabolic pathways. Expand
Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.
The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes membrane phospholipids by pathways that are generally common to those found in higher eukaryotes. Phospholipid… Expand
Roles of phosphatidate phosphatase enzymes in lipid metabolism.
A gene (PAH1) encoding a PAP1 enzyme was found in Saccharomyces cerevisiae, and this discovery has revealed a molecular function of the mammalian protein lipin, a deficiency of which causes lipodystrophy in mice. Expand
Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes.
The assignment of functions to the remaining unassigned open reading frames, as well as ascertainment of remaining gene-enzyme relationships in phospholipid biosynthesis in yeast, promises to provide detailed understanding of the genetic regulation of a crucial area of metabolism in a key eukaryotic model system. Expand
Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae*
The pathways generating and utilizing PA in yeast and the evidence that PA plays a central role in the transcriptional regulation of glycerophospholipid synthesis are focused on. Expand
The Cellular Functions of the Yeast Lipin Homolog Pah1p Are Dependent on Its Phosphatidate Phosphatase Activity*
The results demonstrated that the PAP1 activity of the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology. Expand
An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth*♦
- G. Han, L. O’Hara, G. Carman, S. Siniossoglou
- Biology, Medicine
- Journal of Biological Chemistry
- 18 July 2008
Dgk1p is a unique diacylglycerol kinase that uses CTP, instead of ATP, to generate phosphatidate, which is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis. Expand
Phosphatidate phosphatase, a key regulator of lipid homeostasis.
Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol, which plays a crucial role in lipid homeostasis and physiological functions affected by PAP activity include phospholipid synthesis gene expression, nuclear/endoplasmic reticulum membrane growth, lipid droplet formation, and vacuole homeostasi and fusion. Expand
Phosphorylation of Phosphatidate Phosphatase Regulates Its Membrane Association and Physiological Functions in Saccharomyces cerevisiae
- Hyeon-Son Choi, Wen-Min Su, +5 authors G. Carman
- Biology, Medicine
- The Journal of Biological Chemistry
- 16 November 2010
Phosphorylation-deficient PAP (PAP-7A) containing alanine substitutions for the seven phosphorylation sites bypassed the requirement of the phosphatase complex and complemented the pah1Δ nem 1Δ mutant phenotypes, such as temperature sensitivity, nuclear/endoplasmic reticulum membrane expansion, decreased triacylglycerol synthesis, and derepression of INO1 expression. Expand