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Diabetic Ketoacidosis Promotes a Prothrombotic State
Cerebrovascular accidents are one of the life‐threatening complications of diabetic ketoacidosis (DKA) in children and adolescents. Our objective was to evaluate the effect of DKA and its treatment… Expand
Intra-individual open comparison of burst-suppression-isoflurane-anaesthesia versus electroconvulsive therapy in the treatment of severe depression.
Isoflurane anaesthesia was proposed instead of electro-convulsive therapy (ECT) in patients with treatment-refractory depression. This open study compared burst-suppression-isoflurane-anaesthesia… Expand
Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis.
- D. Lee, W. Hoffman, G. Carl, M. Khichi, P. Cornwell
- Journal of diabetes and its complications
- 1 July 2002
Oxidative stress plays an important role in the chronic complications of insulin-dependent diabetes mellitus (IDDM). Hyperketonemia, as well as hyperglycemia, is involved in the generation of… Expand
Association of low blood manganese concentrations with epilepsy
A comparison of hospitalized epileptic patients with matched normals showed that the mean whole blood manganese (Mn) G concentration of the epileptic population was significantly lower than the mean… Expand
Phenytoin treatment and folate supplementation affect folate concentrations and methylation capacity in rats.
- G. Carl, M. L. Smith, G. M. Furman, I. Eto, R. Schatz, C. Krumdieck
- Biology, Medicine
- The Journal of nutrition
- 1 August 1991
Phenytoin (PHT) has long been known to cause folate depletion with chronic use. In animal models PHT has been shown to interfere with folate-dependent one-carbon metabolism. Folic acid… Expand
Four enzymes of one-carbon metabolism in blood cells of schizophrenics.
Characterization of a nicotinic acetylcholine receptor from rabbit skeletal muscle and reconstitution in planar phospholipid bilayers.
- R. J. Bradley, J. H. Howell, W. Romine, G. Carl, G. Kemp
- Chemistry, Medicine
- Biochemical and biophysical research…
- 26 January 1976
Abstract The nicotinic acetylcholine receptor from rabbit skeletal muscle was isolated by affinity chromatography and characterized by 125 I- α -Bungarotoxin binding and gel filtration… Expand
Chronic Carbamazepine Treatment in the Rat: Efficacy, Toxicity, and Effect on Plasma and Tissue Folate Concentrations
Summary: Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was… Expand
Effect of kainate-induced seizures on tissue trace element concentrations in the rat
- G. Carl, J. W. Critchfield, J. L. Thompson, L. S. Mcginnis, C. Keen
- Chemistry, Medicine
- 31 December 1989
It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of… Expand
Chronic treatment of rats with primidone causes depletion of pteroylpentaglutamates in liver.
Anticonvulsants have been shown to cause folacin deficiency in chronically treated epileptic patients. However, a mechanism for this depletion has not been established. In the present study, the… Expand