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Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.
- M. Sedeek, G. Callera, +8 authors R. L. Hébert
- Chemistry, Medicine
- American journal of physiology. Renal physiology
- 1 December 2010
Molecular mechanisms underlying renal complications of diabetes remain unclear. We tested whether renal NADPH oxidase (Nox) 4 contributes to increased reactive oxygen species (ROS) generation and… Expand
Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II) into angiotensin (1-7) [Ang(1-7)], a peptide reported to have vasodilatory and cardioprotective properties.… Expand
Aldosterone Activates Vascular p38MAP Kinase and NADPH Oxidase Via c-Src
Increasing evidence indicates that aldosterone elicits vascular effects through nongenomic signaling pathways. We tested the hypothesis that aldosterone induces activation of vascular… Expand
Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways: Implications in Diabetes Mellitus–Associated Obesity and Vascular Dysfunction
We reported aldosterone as a novel adipocyte-derived factor that regulates vascular function. We aimed to investigate molecular mechanisms, signaling pathways, and functional significance of… Expand
Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src–Regulated Redox-Sensitive RhoA Pathways
- A. Montezano, G. Callera, +5 authors R. Touyz
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 August 2008
Objective—Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular inflammation, fibrosis, and remodeling. Molecular mechanisms underlying this… Expand
Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1–Independent Pathways in Human…
Rationale: Although Nox5 (Nox2 homolog) has been identified in the vasculature, its regulation and functional significance remain unclear. Objectives: We sought to test whether vasoactive agents… Expand
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
- G. Callera, R. Tostes, A. Yogi, A. Montezano, R. Touyz
- Medicine, Chemistry
- Clinical science
- 1 February 2006
We have demonstrated recently [Callera, Touyz, Teixeira, Muscara, Carvalho, Fortes, Schiffrin and Tostes (2003) Hypertension 42, 811-817] that increased vascular oxidative stress in DOCA… Expand
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR.
- A. Briones, F. Tabet, +6 authors R. Touyz
- Journal of the American Society of Hypertension…
- 1 May 2011
The functional significance and regulation of NAD(P)H oxidase (Nox) isoforms by angiotensin II (Ang II) and endothelin-1 (ET-1) in vascular smooth muscle cells (VSMCs) from normotensive Wistar-Kyoto… Expand
Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation.
- T. Bruder-Nascimento, P. Chinnasamy, +5 authors N. Sibinga
- Biology, Medicine
- Journal of molecular and cellular cardiology
Fat1 is an atypical cadherin that controls vascular smooth muscle cell (VSMC) proliferation and migration. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (Nox1) is an important source… Expand
ETA Receptor Blockade Decreases Vascular Superoxide Generation in DOCA-Salt Hypertension
Abstract—Development and progression of end-organ damage in hypertension have been associated with increased oxidative stress. Superoxide anion accumulation has been reported in deoxycorticosterone… Expand