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PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation
In fibroblasts, thrombin induces collagen deposition through activation of a G‐protein–coupled receptor, proteinase‐activated receptor 1 (PAR1). In the current study, we examined whether PAR1Expand
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Enhanced activity of a hydrogen sulphide‐releasing derivative of mesalamine (ATB‐429) in a mouse model of colitis
Mesalamine is the first‐line therapy for colitis, but it lacks potency and is only effective for mild‐to‐moderate forms of this disease. Hydrogen sulphide has been shown to be a potent, endogenousExpand
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Markedly reduced toxicity of a hydrogen sulphide‐releasing derivative of naproxen (ATB‐346)
Background and purpose:  Hydrogen sulphide is an important mediator of gastric mucosal defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their toxicity,Expand
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5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of
H2S functions as a neuromodulator and exerts anti-inflammatory activities. Recent data indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. In thisExpand
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Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat.
BACKGROUND & AIMS Gastrointestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important contribution to mucosal defense,Expand
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Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart.
Protease-activated receptor-2 (PAR-2) is a member of seven transmembrane domain G protein-coupled receptors activated by proteolytic cleavage whose better known member is the thrombin receptor. TheExpand
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Pharmacological dissection of vascular effects caused by activation of protease‐activated receptor 1 and 2 in anesthetized rats
To clarify the role of protease‐activated receptor 1 and 2 (PAR‐1 and PAR‐2) in controlling blood pressure, we evaluated changes in blood pressure induced by a peptide that activates the receptorExpand
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Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals.
Giuseppe Caliendo,* Giuseppe Cirino, Vincenzo Santagada, and John L. Wallace Dipartimento di Chimica Farmaceutica e Tossicologica, and Dipartimento di Farmacologia Sperimentale, Universit a degliExpand
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5-HT(1A) receptor: an old target as a new attractive tool in drug discovery from central nervous system to cancer.
The serotonin receptor subtype 5-HT(1A) was one of the first serotonin receptor subtypes pharmacologically characterized. This receptor subtype has long been object of intense research and isExpand
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Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.
A recombinant dengue 2 virus NS2B-NS3 protease (NS means non-structural virus protein) was compared with human furin for the capacity to process short peptide substrates corresponding to seven nativeExpand
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