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Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
TLDR
An overview of issues confirms that anthracyclines remain “evergreen” drugs with broad clinical indications but have still an improvable therapeutic index. Expand
Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype.
TLDR
It is proposed that the iron-release-associated phenotype of alternatively activated macrophages significantly contributes to their role in various conditions, including tissue repair and tumor growth. Expand
Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor
TLDR
Monitoring IRP activities in H9c2 rat embryo cardiomyocytes exposed to DOX or to analogues revealed that IRP-2 was inactivated only by ROS, serving guidelines for designing anthracyclines that spare iron homeostasis and induce less severe cardiotoxicity. Expand
HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.
TLDR
The results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of SOTA to expand the extent of response to iron deficiency. Expand
The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.
TLDR
The role of IRP is reviewed in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest. Expand
Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
TLDR
The present review applies a multisided approach to the critical evaluation of various hypotheses proposed over the last decade for the role of iron in anthracycline‐induced cardiotoxicity to build a unifying pattern that would both account for hitherto unexplained experimental observations and help design novel and more rational strategies toward a much‐needed improvement in the therapeutic index of anthRacyclines. Expand
Differential regulation of iron homeostasis during human macrophage polarized activation
TLDR
The distinct regulation of iron homeostasis in M2 macrophages provides insights into their role under pathophysiological conditions. Expand
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity.
TLDR
Evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin is reviewed, as well as evidence supporting a novel function as a signalling molecule and immune regulator. Expand
Iron regulatory proteins in pathobiology.
TLDR
In response to fluctuations in the level of the 'labile iron pool', IRPs act as key regulators of cellular iron homoeostasis as a result of the translational control of the expression of a number of iron metabolism-related genes. Expand
A precious metal: Iron, an essential nutrient for all cells
TLDR
This review presented an overview of the remarkable new insights that over the last years have been gained into the multifaceted and sophisticated molecular mechanisms controlling iron acquisition, storage and release. Expand
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