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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Despite a long-suspected role in the development of human colorectal cancer (CRC), the composition of gut microbiota in CRC patients has not been adequately described. In this study, fecal bacterial… Expand
Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS.
Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis and… Expand
Urinary metabonomic study on colorectal cancer.
After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J. Proteome Res., we profiled urine metabolites from the same group of CRC patients (before and after… Expand
Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer
BackgroundColorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many tumors and their… Expand
MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2
microRNA-27a (miR-27a) is frequently dysregulated in human carcinoma, including gastric cancer. The B-cell translocation gene 2 (BTG2) has been implicated in gastric carcinogenesis. However, till… Expand
Metabonomics identifies serum metabolite markers of colorectal cancer.
- Binbin Tan, Yunping Qiu, +16 authors W. Jia
- Chemistry, Medicine
- Journal of proteome research
- 29 May 2013
Recent studies suggest that biofluid-based metabonomics may identify metabolite markers promising for colorectal cancer (CRC) diagnosis. We report here a follow-up replication study, after a previous… Expand
miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2
MicroRNAs (miRNAs) are important regulators involved in various cancers, including colorectal cancer (CRC). The functions and mechanisms of the miRNAs involved in CRC progress and metastasis are… Expand
A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential
Purpose: Metabolic phenotyping has provided important biomarker findings, which, unfortunately, are rarely replicated across different sample sets due to the variations from different analytical and… Expand
Prognostic Significance of the Metastatic Lymph Node Ratio in Node-Positive Rectal Cancer
BackgroundThe purpose of the study was to evaluate the prognostic value of metastatic lymph node ratio (LNR) in node-positive rectal cancer.MethodsA retrospective review was performed in 318 rectal… Expand
Clinicopathological Features and Prognostic Factors of Rectal Gastrointestinal Stromal Tumors
AimRectal gastrointestinal stromal tumor (GIST) was a rare disease. This study sought to summarize clinicopathological features and prognostic factors of rectal GISTs.MethodsClinicopathological… Expand