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Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonaryExpand
Activation of GPER ameliorates experimental pulmonary hypertension in male rats
Rationale: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right‐ventricle (RV) failure, and premature death.Expand
The Hypnotic, Anxiolytic, and Antinociceptive Profile of a Novel µ-Opioid Agonist
5′-4-Alkyl/aryl-1H-1,2,3-triazole derivatives PILAB 1–12 were synthesized and a pharmacological screening of these derivatives was performed to identify a possible effect on the Central NervousExpand
Antinociception induced by a novel &agr;2A adrenergic receptor agonist in rodents acute and chronic pain models
Abstract The mechanisms and antinociceptive effects of a novel &agr;2A adrenoceptor agonist, 3‐(2‐chloro‐6‐fluorobenzil)‐imidazolinide‐2,4‐dione (PT‐31) were investigated using animal models of acuteExpand
Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation
Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays an important role in its pathophysiology. In vitro,Expand
Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
Aims: Pulmonary arterial hypertension (PAH) is a disease characterized by an increase in pulmonary vascular resistance and right ventricular (RV) failure. We aimed to determine the effects of humanExpand
Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and is associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new estrogen receptor (GPER)Expand
Novel agonist of α4β2* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain
Objective To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)–1H-pyrazol-4-yl]ethyl}piperidine), a novel selective α4β2* nicotinicExpand
Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats
Pulmonary arterial hypertension (PAH) is characterized by the remodeling of pulmonary arteries, with an increased pulmonary arterial pressure and right ventricle (RV) overload. This work investigatedExpand
Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain
Introduction New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli by neuron hyperpolarizationExpand