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Functional significance of cell volume regulatory mechanisms.
To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specificallyExpand
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The Diversity of Volume Regulatory Mechanisms
Mammalian cells utilize a wide variety of cell volume regulatory mechanisms. For rapid adjustment of cell volume cells release or accumulate ions through respective channels and transport systemsExpand
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L-selectin activates the Ras pathway via the tyrosine kinase p56lck.
Selectins mediate rolling, the initial step of leukocyte adhesion to endothelial cells [Springer, T. A. (1995) Annu. Rev. Physiol. 57, 827-872 and Butcher, E. C. (1991) Cell 67, 1033-1036]. In thisExpand
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The role of the IsK protein in the specific pharmacological properties of the IKs channel complex
IKs channels are composed of IsK and KvLQT1 subunits and underly the slowly activating, voltage‐dependent IKs conductance in heart. Although it appears clear that the IsK protein affects both theExpand
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L-selectin regulates actin polymerisation via activation of the small G-protein Rac2.
L-selectin mediated adhesion to endothelial cells is a crucial step in the immune response to pathogens (1, 2) and in lymphocyte homing (3, 4). Selectin molecules mediate leukocyte rolling onExpand
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Ion channels involved in insulin release are activated by osmotic swelling of pancreatic B-cells.
Measurements of the membrane potential showed that osmotic swelling (-80 mosmol/l) of pancreatic B-cells led to a transient hyperpolarization followed by a more sustained depolarization of the cellExpand
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Ca2+ entry and vasoconstriction during osmotic swelling of vascular smooth muscle cells
Exposure of aortic strips from guinea-pigs to hypotonic extracellular fluid is followed by marked vasoconstriction, which is inhibited by D-600 (3 μM), a blocker of voltage-sensitive Ca2+ channels.Expand
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Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes.
Cell swelling is shown to induce an increase in acridine orange fluorescence intensity, an effect pointing to the alkalinization of acidic vesicles. Since autophagic hepatic proteolysis isExpand
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Mesangial cell hypertrophy induced by NH4Cl: role of depressed activities of cathepsins due to elevated lysosomal pH.
Enhanced ammoniagenesis is currently thought to play an important role in renal hypertrophy and subsequent tubulointerstitial fibrosis. Under certain conditions glomeruli also may be affected byExpand
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Alkalinization of acidic cellular compartments following cell swelling
Osmotic swelling of rat hepatocytes increases fluorescence of Acridine orange and of fluorescein isothiocyanate (FITC)‐dextran, both indicative of alkalinization of acidic intracellular vesicles.Expand
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