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Receptors for purines and pyrimidines.
### A. Overview Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are important signaling molecules that mediate diverse biological effects via cell-surface receptorsExpand
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Is there a basis for distinguishing two types of P2-purinoceptor?
It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity ofExpand
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Molecular cloning and characterization of rat P2Y4 nucleotide receptor
An intronless open reading frame encoding a protein (361aa in length) was isolated from a rat genomic library probed with a DNA fragment from rat heart. This protein showed 83% sequence identity withExpand
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Purinergic nerves.
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Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor
Under voltage‐clamp conditions, the activity of agonists and antagonists at a recombinant P2X2 receptor expressed in Xenopus oocytes was examined at different levels of extracellular pH (pHe). InExpand
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Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut
1 . Stimulation of the vagal non‐adrenergic inhibitory innervation caused the release of adenosine and inosine into vascular perfusates from the stomachs of guinea‐pigs and toads. 2 . Stimulation ofExpand
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Full sensitivity of P2times2 purinoceptor to ATP revealed by changing extracellular pH
A full pharmacological characterization was carried out on a recombinant ATP‐gated ion channel (P2times2 purinoceptor) expressed in Xenopus oocytes. This slowly‐desensitizing neuronal P2times2Expand
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Coexpression of Rat P2X2 and P2X6Subunits in Xenopus Oocytes
Transcripts for P2X2 and P2X6 subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X2 (rP2X2) and rat P2X6 (rP2X6) receptors were expressed individuallyExpand
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Evidence That Release of Adenosine Triphosphate From Endothelial Cells During Increased Shear Stress Is Vesicular
In response to increased shear stress, vascular endothelial cells release adenosine triphosphate (ATP) by an unknown mechanism. We have investigated this mechanism using different approaches. First,Expand
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Modulation of ATP‐responses at recombinant rP2X4 receptors by extracellular pH and zinc
The modulatory effects of extracellular H+ and Zn2+ were tested against ATP‐responses at rat P2X4 (rP2X4) receptors expressed in Xenopus oocytes under voltage‐clamp conditions. ATP (0.1–100 μM, at pHExpand
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