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Extracellular Vesicles in Luminal Fluid of the Ovine Uterus
Microvesicles and exosomes are nanoparticles released from cells and can contain small RNAs, mRNA and proteins that affect cells at distant sites. In sheep, endogenous beta retroviruses (enJSRVs) areExpand
Extracellular Vesicles Originate from the Conceptus and Uterus During Early Pregnancy in Sheep1
ABSTRACT Cells release diverse types of membrane-bound vesicles of endosomal and plasma membrane origin, termed exosomes and microvesicles, respectively. Extracellular vesicles (EVs) represent anExpand
Oviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?1
ABSTRACT This study examined the effect of the presence of single or multiple embryos on the transcriptome of the bovine oviduct. In experiment 1, cyclic (nonbred, n = 6) and pregnant (artificiallyExpand
Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol
The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition andExpand
Progesterone effects on extracellular vesicles in the sheep uterus†
Abstract Progesterone (P4) acts via the endometrium to promote conceptus growth and implantation for pregnancy establishment. Many cells release extracellular vesicles (EVs) that are membrane-boundExpand
Analysis of the Uterine Epithelial and Conceptus Transcriptome and Luminal Fluid Proteome During the Peri-Implantation Period of Pregnancy in Sheep1
ABSTRACT Studies support the idea that uterine epithelia and their secretions have important biological roles in conceptus survival, elongation, and implantation in sheep. The present study evaluatedExpand
Peroxisome Proliferator Activator Receptor Gamma (PPARG) Regulates Conceptus Elongation in Sheep1
ABSTRACT The ovine blastocyst hatches from the zona pellucida by Day 8 and develops into an ovoid or tubular conceptus (embryo and associated extraembryonic membranes) that grows and elongates into aExpand
Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation
Uterine glands are essential for pregnancy in mice and likely humans, because they secrete or transport bioactive substances that regulate uterine receptivity for blastocyst implantation. In mice,Expand
Identification of Beef Heifers with Superior Uterine Capacity for Pregnancy1
ABSTRACT Infertility and subfertility represent major problems in domestic animals and humans, and the majority of embryonic loss occurs during the first month of gestation that involves pregnancyExpand
Transforming growth factor beta 1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen.
We have recently shown that transforming growth factor-beta 1 (TGF beta 1) is produced in the rat pituitary gland and inhibits the secretion of PRL and the estrogen-induced growth of lactotropes. InExpand