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Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
Cation-selective P2X receptor channels were first described in sensory neurons1-4 where they are important for primary afferent neurotransmission and nociception5,6. Here we report the cloning of aExpand
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Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, theExpand
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A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
EXTRACELLULAR ATP exerts its effects through P2 purino-ceptors1: these are ligand-gated ion channels (P2x)2,3 or G-protein-coupled receptors (Piv, Piu)4- ATP at P2X receptors mediates synapticExpand
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Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).
cDNAs encoding P2x purinoceptors from human bladder smooth muscle and from rat PC-12 cells were expressed in oocytes and human embryonic kidney 293 cells. Agonist potencies of 2-methylthio-ATP =Expand
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Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.
1. Complementary DNAs for the ATP‐gated ion channel subunits P2X1 (from human bladder) and P2X2 (from rat phaeochromocytoma (PC12) cells) were used to express the receptors in human embryonic kidneyExpand
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Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals
Of the cloned P2X receptor subunits, six are expressed in sensory neurons, suggesting that the native channels may be heteromultimers with diverse composition. It has been proposed that P2X2 and P2X3Expand
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Tissue distribution of the P2X7 receptor
The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allowsExpand
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P2X3 is expressed by DRG neurons that terminate in inner lamina II
The P2X3 receptor subunit, a member of the P2X family of ATP‐gated ion channels, is almost exclusively localized in sensory neurons. In the present study, we sought to gain insight into the role ofExpand
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Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.
Several P2X receptor subunits were recently cloned; of these, one was cloned from the rat vas deferens (P2X1) and another from pheochromocytoma (PC12) cells differentiated with nerve growth factorExpand
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Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors
P2X1 receptors for ATP are ligand-gated cation channels, present on many excitable cells including vas deferens smooth muscle cells. A substantial component of the contractile response of the vasExpand
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