G. Brunelle

Publications93
h-index9
Citations419
Highly Influential Citations10
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Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats.
In order to determine whether the morphological modifications observed in arterial media of spontaneously hypertensive rats (SHR) could be induced by an abnormal response of the smooth muscle cells… Expand
  • 177
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Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.
  • F. Roman, S. Lanet, +6 authors M. Gola
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 June 1999
Trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxybenzoate hydrogen maleate (TMB)] has been demonstrated to be active for relieving abdominal pain in humans. To better understand its… Expand
  • 39
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A randomized double blind trial of dialysate sodiums of 145 mEq/L, 150 mEq/L, and 155 mEq/L.
Most hemodialysis is now carried out with a dialysate sodium concentration of 140-145 mEq/L. Higher dialysate sodium has been used, but controversy exists concerning the increased incidence of high… Expand
  • 34
  • 2
JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices.
JO1784, a potent and specific sigma ligand, potentiated the KCl-evoked release of [3H]acetylcholine (ACh) from rat hippocampal slices superfused in vitro at 10 and 30 microM. This effect was… Expand
  • 12
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Between Crown and Commerce Marseille and the Early Modern Mediterr anean
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Role of nuclear proto-oncogenes in the proliferation of aortic smooth muscle cells in spontaneously hypertensive rats.
In order to define the molecular mechanism involved in the enhancement of spontaneously hypertensive rat (SHR) cell proliferation, we compared the actions of fetal calf serum and angiotensin II on… Expand
  • 8
Occurrence of the methylisobutylxanthine-stimulated cyclic GMP binding protein in various rat tissues.
A new type of cGMP binding protein, the activity of which is characteristically stimulated by methylisobutylxanthine, has been previously discovered in rat lung and platelets (Hamet, P. and Coquil,… Expand
  • 19
Adenylate cyclase of platelets from spontaneously hypertensive rats: reduction of the inhibition by GTP.
We have compared the effects of Gpp[NH]p on adenylate cyclase activity of platelet membranes in SHR and WKY rats. In the presence of 50 microM forskolin, low concentrations of Gpp[NH]p (0.01 to 0.3… Expand
  • 7
Activity of cyclic GMP-dependent protein kinase in aortae from spontaneously hypertensive rats.
It has been suggested that various agents induce relaxation of vascular smooth muscles through guanosine 3',5'-cyclic monophosphate (cGMP) and cGMP-dependent protein kinase (cGMP-PK). In this work,… Expand
  • 6
Hyperactivation of phospholipase C does not support the enhanced proliferation of aortic smooth muscle cells from spontaneously hypertensive rats.
When cultured in the presence of fetal calf serum, arterial smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate more rapidly and are more numerous at confluency than cells from… Expand
  • 3