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Iron-chelating therapy and the treatment of thalassemia.
The toxicity of this agent mandates a careful evaluation of the balance between risk and benefit of deferiprone in patients with thalassemia, in most of whom long-term deferoxamine is safe and efficacious therapy.
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara.
- C. Beall, G. Brittenham, C. Gonzales
- Environmental ScienceAmerican journal of physical anthropology
- 1 July 1998
The present study tested the null hypothesis of no difference in mean hemoglobin concentration of Tibetan and Aymara native residents at 3,800-4,065 meters by using healthy samples that were screened for iron deficiency, abnormal hemoglobins, and thalassemias, recruited and assessed using the same techniques.
Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major.
The early use of deferoxamine in an amount proportional to the transfusional iron load reduces the body iron burden and helps protect against diabetes mellitus, cardiac disease, and early death in patients with thalassemia major.
Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial.
- M. Cogswell, I. Parvanta, Liza Ickes, R. Yip, G. Brittenham
- MedicineThe American journal of clinical nutrition
- 1 October 2003
Iron supplementation from enrollment to 28 wk of gestation did not significantly affect the overall prevalence of anemia or the incidence of preterm births but led to a significantly higher mean (+/- SD) birth weight.
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection.
The results support the conjecture that the HbE mutation occurred recently, and the allele frequency has increased rapidly, and provide another clear demonstration that a high-resolution LD map across the human genome can detect recent variants that have been subjected to positive selection.
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.
Deferiprone does not adequately control body iron burden in patients with thalassemia and may worsen hepatic fibrosis.
Magnetic-susceptibility measurement of human iron stores.
- G. Brittenham, D. Farrell, E. Bellon
- Medicine, BiologyThe New England journal of medicine
- 30 December 1982
We made direct noninvasive magnetic measurements of hepatic iron stores with a specially designed superconducting quantum-interference-device (SQUID) susceptometer in 20 normal subjects and in 110…
Noninvasive measurement of iron: report of an NIDDK workshop.
A clear clinical need is evident for quantitative, noninvasive, safe, accurate, and readily available means of measuring body storage iron to improve the diagnosis and management of patients with iron overload from such disorders as hereditary hemochromatosis, thalassemia major, sickle cell disease, aplastic anemia, and myelodysplasia.
An Ethiopian pattern of human adaptation to high-altitude hypoxia
- C. Beall, M. Decker, G. Brittenham, I. Kushner, A. Gebremedhin, K. Strohl
- Biology, MedicineProceedings of the National Academy of Sciences…
- 5 December 2002
Ethiopian highlanders maintain venous hemoglobin concentrations and arterial oxygen saturation within the ranges of sea level populations, despite the unavoidable, universal decrease in the ambient oxygen tension at high altitude.
Experimental liver cirrhosis induced by alcohol and iron.
Evidence is provided for a critical role of iron and iron-catalyzed oxidant stress in progression of alcoholic liver disease by intragastrically infused rats with or without ethanol to determine if alcoholic liver fibrogenesis is exacerbated by dietary iron supplementation.