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Polyethylene multiwalled carbon nanotube composites
Polyethylene (PE) multiwalled carbon nanotubes (MWCNTs) with weight fractions ranging from 0.1 to 10 wt% were prepared by melt blending using a mini-twin screw extruder. The morphology and degree ofExpand
Comparison of two assays, a faecal egg count reduction test (FECRT) and a coproantigen reduction test (CRT), for the diagnosis of resistance to triclabendazole in Fasciola hepatica in sheep.
Results supported the use of both the FECRT and the CRT for the diagnosis of resistance of Fasciola hepatica to triclabendazole (TCBZ), and confirmed the TCBZ susceptibility of the Cullompton and Fairhurst F. Hepatica isolates and the TCbZ resistance of the Oberon F. hepaticA isolate. Expand
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
The role of antibody and T cell responses in mediating protection and the prospects of the cathepsin Ls in the development of first generation recombinant liver fluke vaccines are reviewed. Expand
Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica.
Immunolocalisation studies revealed that the cathepsin L-like proteinase is concentrated within vesicles in the gut epithelial cells of liver fluke. Expand
Understanding triclabendazole resistance.
An overview of progress in understanding the mechanism of resistance toTCBZ is presented, examining possible changes in the target molecule, in drug influx/efflux mechanisms and in the metabolism of TCBZ by the fluke. Expand
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration.
The successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs) resulted in marked reductions in target transcript levels and significant diminution in the encoded proteins in the gut. Expand
Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) Virulence
The results indicate that activation of procathepsin L1 by removal of the propeptide can occur by different pathways, and that this takes place within the parasite gut where the protease functions in food digestion and from where it is liberated as an active enzyme for additional extracorporeal roles. Expand
Standardisation of a coproantigen reduction test (CRT) protocol for the diagnosis of resistance to triclabendazole in Fasciola hepatica.
Study results suggest that low to moderate temperature has little, if any, impact on coproantigen stability in faecal samples, but that higher temperatures may have. Expand
Bovine paramphistomes in Ireland.
Although the clinical significance of C. daubneyi is still uncertain, considering the apparent pervasiveness of the parasite, rumen fluke should be considered a differential diagnosis when treating scour or ill-thrift in young calves, and goats and sheep of any age. Expand
Isolation, Localization, and Bioactivity of the FMRFamide‐Related Neuropeptides GYIRFamide and YIRFamide from the Marine Turbellarian Bdelloura candida
An important role is indicated for GYIRFamide and YirFamide in the control of neuromuscular function in turbellarians and the structure of the endogenous peptides was optimal for peak activity. Expand