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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitroExpand
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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen
We describe the phenotype of gene-targeted mice lacking the putative chemokine receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a subpopulation of T helper cells. Blr1Expand
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Partial impairment of cytokine responses in Tyk2-deficient mice.
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where inactivation leads to a complete loss of the respective cytokineExpand
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Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation
Neurotrophin-3 (NT-3) is required for the development of most sensory neurons of the dorsal root ganglia. Using electrophysiological techniques in mice with null mutations of the NT-3 gene, we showExpand
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Microsatellite diversity, population subdivision and gene flow in the Lipizzan horse.
Blood samples of 561 Lipizzan horses from subpopulations (studs) of seven European countries representing a large fraction of the breed's population were used to examine the genetic diversity,Expand
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Disruption of the CNTF gene results in motor neuron degeneration
CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a sub-population of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determinedExpand
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High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates.
Within recent years, microsatellite have become one of the most powerful genetic markers in biology. For several mammalian species, microsatellite mutation rates have been estimated on the order ofExpand
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Detection and characterization of SNPs useful for identity control and parentage testing in major European dairy breeds.
We propose the use of single nucleotide polymorphisms (SNPs) instead of polymorphic microsatellite markers for individual identification and parentage control in cattle. To this end, we present anExpand
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Chimeric pigs following blastocyst injection of transgenic porcine primordial germ cells
Porcine primordial germ cell (PGC) derived cell lines of WAPhGH‐transgenic pigs have been established that were able to contribute to chimeras. PGCs were isolated from day 25 to 28 genital ridges ofExpand
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Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pretreatment and injection technique.
Intracytoplasmic sperm injection (ICSI) is a very important technique for treating male subfertility and for basic research. The efficiency of ICSI in bovine is very limited because of the necessityExpand
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