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Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine
In patients given acetylcysteine, progression to grade III/IV coma was significantly less common than in those who did not receive the antidote, although the median peak prothrombin time was similar for both groups. Expand
Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result?
The findings suggest that serum from AI-CAH patients may contain a component that gives false-positive results in the assay, and this component may be associated with immunosuppressant therapy. Expand
Non-invasive assessment of bone density in primary biliary cirrhosis.
- S. Pereira, G. Bray, P. Pitt, F. Li, C. Moniz, R. Williams
- European journal of gastroenterology & hepatology
- 1 March 1999
Low bone mass in PBC correlates positively with disease severity, and is associated with a net increase in bone resorption, as assessed by urinary collagen cross-link excretion. Expand
Pancreatic abnormalities and AIDS related sclerosing cholangitis.
Pancreatic abnormalities are commonly seen with AIDS related sclerosing cholangitis and may be responsible for some of the pain not relieved by biliary sphincterotomy. Expand
Susceptibility to primary biliary cirrhosis is associated with the HLA‐DR8‐DQB1*0402 haplotype
- J. Underhill, P. Donaldson, G. Bray, D. Doherty, B. Portmann, R. Williams
- Biology, Medicine
- 1 December 1992
The data reported here confirm the findings of previous studies, although the described association with DR8 is considerably weaker, and the weak genetic contribution of human leukocyte antigen in the susceptibility to primary biliary cirrhosis is in contrast to its role in other autoimmune liver diseases. Expand
Prevalence and pattern of familial disease in primary biliary cirrhosis.
It is concluded that familial PBC is not rare, that it is related to maternally inherited factors, and that disease tends to present earlier in the second generation. Expand
Long-Term Anticonvulsant Therapy Worsens Outcome in Paracetamol-Induced Fulminant Hepatic Failure
- G. Bray, P. Harrison, J. O'grady, J. Tredger, R. Williams
- Human & experimental toxicology
- 1 July 1992
It is concluded that chronic use of anticonvulsants enhances clinical features of paracetamol toxicity and possible mechanisms by which this could be mediated are discussed. Expand
The Effect of Chronic Alcohol Intake on Prognosis and Outcome in Paracetamol Overdose
- G. Bray, C. Mowat, D. Muir, J. Tredger, R. Williams
- Human & experimental toxicology
- 1 November 1991
Chronic alcohol intake above suggested limits is an adverse prognostic feature in cases of severe paracetamol overdose and is partly related to increased nephrotoxicity. Expand
S‐adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models
S‐adenosylmethionine promotes synthesis of hepatic glutathione in chronic liver disease and is well tolerated in man, and its use as an antidote to acetaminophen hepatotoxicity in two mouse models is investigated. Expand
Comparison of serum procollagen III peptide concentrations and PGA index for assessment of hepatic fibrosis
Substantially raised PIIIP concentrations identify the subgroup of alcoholic patients with both hepatitis and cirrhosis and may be useful for targeting treatment with antifibrotic drugs and to reduce the need for liver biopsy. Expand