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Improvement of cognitive function by MAO-B inhibitor L-deprenyl in aged rats
This study evaluated the ability of the selective MAO-B inhibitor, L-deprenyl, to reverse cognitive impairments appearing in aged rats, using the reference memory, Morris Water Maze paradigm.Expand
Peri- and postnatal, teratology and reproductive studies of a low molecular weight heparin in rats.
The low molecular weight heparin (OP/LMWH) used in these studies elicited no evidence of teratogenicity when administered by subcutaneous route during the period of organogenesis to pregnant rats atExpand
Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats.
Groups of 50 male and 50 female Sprague-Dawley rats were given food containing sufficient doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. These dosagesExpand
Morphological and biochemical effects of intrahepatic alcohol injection in the rabbit
The local and systemic effects, as well as the repair mechanisms, of sterile absolute ethyl alcohol injection were evaluated at a range of doses (0.1–2.0 mL/kg body weight) in rabbit liver in orderExpand
Toxic and mutagenic effects of a low molecular weight heparin in rats.
Acute, subacute, chronic toxicity and mutagenicity studies of a new low molecular weight heparin (OP/LMWH) were carried out in rats. The LD50 values resulted lower by i.m. and s.c. route than afterExpand
Ipriflavone does not alter bone apatite crystal structure in adult male rats
We have previously found that a short-term treatment with high doses of ipriflavone increased bone density and improved the biomechanical properties of adult male rat bones, without altering theirExpand
Acute, subacute, chronic toxicity and mutagenicity studies of rifaximin (L/105) in rats.
Acute, subacute and chronic toxicity-mutagenicity studies of rifaximin (L/105), a new semisynthetic rifamycin SV antibiotic, were conducted in rats. The oral LD50 value for this species was greaterExpand
[Teratogenic action of Rifaximin in the rat and rabbit and its effect on perinatal development in the rat].
The purpose of this study is to evaluate the teratogenic action and the effect on perinatal development of Rifaximin. Teratogenic action of Rifaximin was studied in the rat and in the rabbit. TheExpand
Fertility study of rifaximin (L/105) in rats.
The influence of rifaximin (L/105) on conception and pregnancy in rats up to F1 progeny was reported. Rifaximin showed a good fertility rate and no dose-related differences in the number of viable orExpand