• Publications
  • Influence
Drinking water disinfection byproducts: review and approach to toxicity evaluation.
  • G. Boorman
  • Environmental Science
    Environmental health perspectives
  • 1 February 1999
The approach developed by these agencies to provide the information needed to make scientifically based regulatory decisions is described and a toxicity database that reflects a wide range of DBPs resulting from different disinfection practices is created.
New Insights into Functional Aspects of Liver Morphology
Findings regarding the functional heterogeneity of the various liver cell types, including hepatocytes, hepatic stellate cells, sinusoidal endothelia, and Kupffer cells, are providing new insights into the understanding of the development, prevention and treatment of liver disease.
Urolithiasis and bladder carcinogenicity of melamine in rodents.
Gene expression profiling of rat livers reveals indicators of potential adverse effects.
Evidence is provided that supports the hypothesis that gene expression profiling may be a sensitive means of identifying indicators of potential adverse effects in the absence of the occurrence of overt toxicity.
Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.
Renal Lesions Induced by Ochratoxin A Exposure in the F344 Rat
It is demonstrated that ochratoxin A is a potent renal carcinogen in the F344 rat and contamination of feedstuff by this mycotoxin may pose a potential hazard to domestic animals and man.
Blood gene expression signatures predict exposure levels
The hypothesis that gene expression data from peripheral blood cells can provide valuable information about exposure levels, well before liver damage is detected by classical parameters, supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage.
Use of Historical Control Data in Carcinogenicity Studies in Rodents
Tumor incidence data from untreated Fischer 344 rats and B6C3F1 mice in the National Toxicology Program (NTP) historical control database is summarized.
A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin
Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of Capsaicin is quite low and that the purity of capsicin is important.
Standardizing global gene expression analysis between laboratories and across platforms
It is shown that microarray results can be comparable across multiple laboratories, especially when a common platform and set of procedures are used, and reproducibility between laboratories was generally poor.