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Preferred conformation of the terminally blocked (Aib)10 homo‐oligopeptide: A long, regular 310‐helix
The decapeptide pBrBz‐ (Aib)10‐OtBu, synthesized by the 5(4H)‐oxazolone method, crystallizes in the monoclinic space group C2/c with a = 43.901(2), b = 9.289(2), and c = 34.746(3) A; β = 114.69(3)°;Expand
Sequence‐Dependence of secondary structure formation: Conformational studies of host–guest peptides in α‐helix and β‐structure supporting media
Given the fact that conformational effects are important in peptide synthesis, the tentative scales may serve as a guideline to predict secondary structures of side‐chain‐protected or ‐deprotected peptides in a given solvent, complementing the well‐known empirical conformational prediction parameters. Expand
Peptide Helices as Rigid Molecular Rulers: A Conformational Study of Isotactic Homopeptides from α-Methyl-α-isopropylglycine, [L-(αMe)Val]n†
Terminally blocked, isotactic homopeptides from the sterically demanding α-methylvaline of general formula Y-[L-(αMe)Val]n-OtBu (Y = Z, pBrBz, Ac; n = 2–8) have been prepared step-by-step in solutionExpand
Linear oligopeptides. Part 147. Chemical and crystallographic study of the reaction between benzyloxycarbonyl chloride and α-aminoisobutyric acid
From the reaction mixture of benzyloxycarbonyl chloride and α-aminoisobutyric acid three crystalline compounds were isolated and characterized by chromatographic and spectroscopic techniques andExpand
Antiproliferative activity of a triplex-forming oligonucleotide recognizing a Ki-ras polypurine/polypyrimidine motif correlates with protein binding
Evidence is provided that, in vitro, ODN20 and MPEGODN20 competitively inhibit the binding to the Ki-ras pur/pyr motif of a nuclear protein, suggesting that the activity of MPEG ODn20 occurs with an aptameric mechanism. Expand
Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidite approach.
A new method for the liquid phase synthesis of oligonucleotides is described which makes use of polyethylene glycol (PEG) as soluble support and phosphoramidite derivatives as synthons and appears effective in terms of speed and coupling yield. Expand
Linear oligopeptides. 118. Preferred conformations and modes of self-association of the fluoren-9-ylmethoxycarbonyl amino acid derivatives
An analysis of the preferred conformations and modes of self-association of the N-fluoren-9-methoxycarbonyl derivatives of L-alanine and α-aminoisobutyric acid was performed in solution and in theExpand
Reactive PEGs for protein conjugation
Poly(ethylene glycol) (PEG) derivatives are the first choice of the water soluble, biocompatible polymers on hand for conjugation to proteins and polypeptides. This chapter deals with the PEGExpand