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Tableting Properties of Experimental and Commercially Available Lactose Granulations for Direct Compression
AbstractLactose granulations (125-250 μm) were prepared from two different β-lactose monohydrate powders and one roller dried B-lactose powder respectively, by wet granulation with only water as a
Comparative evaluation of excipients for direct compression
TLDR
The results show that with a knowledge of properties and interactions of drugs, directly compressible excipients and other tablet vehicles, formulations can be composed from which tablets with good properties can be prepared.
The Effect of Magnesium Stearate Admixing in Different Types of Laboratory and Industrial Mixers on Tablet Crushing Strength
AbstractIt is generally known that hydrophobic lubricants such as magnesium stearate can have a strong negative effect on the binding properties of directly compressible filler-binders. It was found
MIXING ACTION AND EVALUATION OF TABLET LUBRICANTS IN DIRECT COMPRESSION
AbstractThe effect of a series of modern lubricants during mixing on both lubricating action and binding properties of a direct compressible tablet formulation has bean investigated and compared with
EVALUATION OF MODIFIED RICE STARCH, A NEW EXCIPIENT FOR DIRECT COMPRESSION
AbstractThe compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an
Native starch in tablet formulations: Properties on compaction
TLDR
Rice starch showed much better compactibility as compared to maize, potato and tapioca starch, and its binding capacity proved to be almost insensitive to mixing with magnesium stearate, in contrast to the dramatic decrease in crushing strength of potato starch tablets containing the lubricant.
Water uptake and disintegrating force measurements: towards a general understanding of disintegration mechanisms
Water penetration and disintegrating force measurements were combined with the aim of assessing the role played by various mechanisms in the disintegration process.Nine tablet series, made of
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