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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at risk of developing significant morbidity and mortality.Expand
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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the DrosophilaExpand
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Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.
A chemically heterogeneous group of compounds, the Ca++ channel antagonists, which includes verapamil, diltiazem and nifedipine inhibits excitation-contraction coupling in smooth and cardiac muscleExpand
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Binding of a new opiate antagonist, nalmefene, to rat brain membranes.
Nalmefene (6-methylene-naltrexone) is a potent, orally active, opiate antagonist. IC50's were obtained for nalmefene, naloxone and naltrexone using radiolabelled prototype ligands for mu, kappa andExpand
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A method for difference cloning: gene amplification following subtractive hybridization.
We describe a procedure for genomic difference cloning, a method for isolating sequences present in one genomic DNA population ("tester") that is absent in another ("driver"). By subtractiveExpand
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High affinity binding of a calcium channel antagonist to smooth and cardiac muscle.
Abstract Specific binding of the Ca 2+ -channel antagonist nitrendipine, a close structural analog of nifedipine, has been measured in microsomal membrane fractions from guinea pig ileal longitudinalExpand
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Local anesthetics differentiate dihydropyridine calcium antagonist binding sites in rat brain and cardiac membranes.
Local anesthetics were used to probe differences in the binding of [3H]nitrendipine to dihydropyridine calcium antagonist binding sites on rat brain and cardiac membranes. Local anesthetics inhibitedExpand
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Characteristics of the binding of [3H]nitrendipine to rabbit ventricular membranes: modification by other Ca++ channel antagonists and by the Ca++ channel agonist Bay K 8644.
This study was carried out to characterize [3H]nitrendipine binding to cardiac membranes and to test the hypothesis that high affinity binding of Ca++ channel antagonists and agonists is to Ca++Expand
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Characterization of the Binding of [3H]Ro 5‐4864, a Convulsant Benzodiazepine, to Guinea Pig Brain
Abstract: The density of high affinity binding sites for [3H]4′‐chlorodiazepam ([3H]Ro 5‐4864) in guinea pig cerebral cortex is significantly higher (3.8‐fold) than the density reported in the rat,Expand
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Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb.
The density of [3H]flunitrazepam and [3H]Ro 5-4864 binding sites was examined 19-21 and 27-31 days after surgical isolation of the olfactory bulbs. While statistically significant reductions inExpand
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