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Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.
TLDR
It is proposed that the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytotic by keratinocytes.
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Melanosomes at a glance
Melanosomes, the pigment granules that provide tissues with colour and photoprotection, are the cellular site of synthesis, storage and transport of melanin pigments. They are synthesised in…
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Co‐localization of IgA and TG3 on healthy skin of coeliac patients
Background  Dermatitis herpetiformis (DH), the skin's expression of coeliac disease (CD), is induced by the presence of IgA antibodies and epidermal transglutaminase (TG3) as the main autoantigen,…
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Melanosome transfer promoted by keratinocyte growth factor in light and dark skin-derived keratinocytes.
TLDR
3D image reconstruction by fluorescence microscopy and ultrastructural analysis through transmission electron microscopy showed differences in the distribution pattern of the beads in light and dark keratinocytes, consistent with the different melanosome distribution in human skin.
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Expression of keratinocyte growth factor and its receptor in clear cell acanthoma
TLDR
Results suggest the inflammatory nature of CCA and support the hypothesis that this disease may represent, like psoriasis, an inflammatory dermatosis in which KGF up‐modulation may be responsible for keratinocyte hyperproliferation and may represent a new common feature of both diseases.
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Loss of Rab27 function results in abnormal lung epithelium structure in mice
TLDR
It is hypothesized that the morphological changes observed at the ultrastructural level in DKO samples result from secretory defects in AEII and Clara cells and that over time these defects lead to atrophy of the epithelium.
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[Some statistical data on the 10-year activity of a Celtic Dispensary of Milan].
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epithelium structure in mice Loss of Rab27 function results in abnormal lung
[Topical treatment of non-gonococcal urethritis with a cortisone-antibiotic-anesthetic comnination in a water soluble vehicle].
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