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Sex differences in the outcome of juvenile social isolation on HPA axis function in rats
Women are more likely than men to suffer from anxiety disorders and major depression. These disorders share hyperresponsiveness to stress as an etiological factor. Thus, sex differences in brainExpand
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Maternal separation attenuates the effect of adolescent social isolation on HPA axis responsiveness in adult rats
Adverse early life experiences that occur during childhood and adolescence can have negative impacts on behavior later in life. The main goal of our work was to assess how the association betweenExpand
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Impaired glucocorticoid-mediated HPA axis negative feedback induced by juvenile social isolation in male rats
ABSTRACT We previously demonstrated that socially isolated rats at weaning showed a significant decrease in corticosterone and adrenocorticotropic hormone (ACTH) levels, associated with an enhancedExpand
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Are preconceptional stressful experiences crucial elements for the aetiology of autism spectrum disorder? Insights from an animal model
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by changes in social interactions, impaired language and communication, fear responses and presence ofExpand
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Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone
RationaleSocial isolation of rats immediately after weaning is thought to represent an animal model of anxiety-like disorders. Socially isolated virgin females showed a significant decrease inExpand
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Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease
For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of variousExpand
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Combined effect of gestational stress and postpartum stress on maternal care in rats
Variations in maternal care in the rat influence the development of individual differences in behavioral and endocrine responses to stress. This study aimed to examine the interaction betweenExpand
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