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A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis
Myoglobin is a typical globular protein, and is found in many animal cells. Like hæmoglobin, it combines reversibly with molecular oxygen; but whereas the role of hæmoglobin is to transport oxygen inExpand
Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid.
Eighteen derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid were assayed for inhibitory activity against neuraminidases from viral and bacterial sources. Twelve of these compounds were activeExpand
Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein.
Based on sequence information from tryptic peptides an almost full-size cDNA coding for the human vascular anticoagulant was isolated from a placental cDNA library and sequenced. The coding regionExpand
Inhibition of influenza and parainfluenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA).
Abstract A synthetic analog of neuraminic acid, 2-deoxy-2,3-dehydro- N -trifluoroacetylneuraminic acid (FANA) is a potent specific inhibitor of neuraminidase. This compound inhibits the elution ofExpand
Periplasmic expression of human interferon-alpha 2c in Escherichia coli results in a correctly folded molecule.
Human interferon-alpha 2c (IFN-alpha 2c) was produced in Escherichia coli under the control of the alkaline phosphatase promoter using a periplasmic expression system. Compared with other leaderExpand
Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.
A cDNA was cloned coding for a new member of the human Ca2+-modulated phospholipid-binding protein family termed annexins. Due to its 56% identity to the human vascular anticoagulant (VAC) the newExpand
Production of monoclonal antibodies to human IFN‐α and their use for analysis of the antigenic composition of various natural interferons
We have established three hybridoma cell lines (designated EBI‐1, ‐2, and ‐3) secreting immunoglobulin G (IgG) antibodies specific for human alpha‐interferon (HuIFN‐α) by fusing P3X63Ag8.6.5.3Expand
Vascular anticoagulant β: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity
A cDNA was cloned coding for a new member of the human Ca2+-modulated phospholipid-binding protein family termed annexins. Due to its 56% identity to the human vascular anticoagulant (VAC) the newExpand
Enhancement of NK, but not K cell activity by different interferons.
Two different interferons derived either from a human lymphoblastoid cell line (Namalva) or from human fibroblasts were tested for their ability to modulate natural killer (NK) or killer (K) cellExpand
Procedures for large-scale production and partial purification of human interferon from lymphocyte (Namalva) cultures.
  • G. Bodo
  • Biology, Medicine
  • Methods in enzymology
  • 1981
Publisher Summary This chapter discusses method for the production and partial purification of interferon from the cells that developed to provide interferon preparations in quantities large enoughExpand
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