• Publications
  • Influence
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.
TLDR
The results indicated that the insulin resistance observed in human muscle when plasma FFA levels were elevated during euglycemic-hyperinsulinemic clamping was associated with increases in DAG mass and membrane-associated PKC-betaII and -delta and a decrease in IkappaB-alpha. Expand
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
TLDR
The results indicated that the insulin resistance observed in human muscle when plasma FFA levels were elevated during euglycemic-hyperinsulinemic clamping was associated with increases in DAG mass and membrane-associated PKC-betaII and -delta and a decrease in IkappaB-alpha. Expand
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
  • G. Boden
  • Biology, Medicine
  • Diabetes
  • 1 January 1997
TLDR
Continuously elevated levels of plasma FFAs may play a key role in the pathogenesis of NIDDM in predisposed individuals by impairing peripheral glucose utilization and by promoting hepatic glucose overproduction. Expand
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
TLDR
Results establish Cdk4 as an essential regulator of specific cell types as well as establishing its role as a regulator of insulin-deficient diabetes and pancreatic hyperplasia in mice expressing a mutant Cdk 4 that cannot bind the cell-cycle inhibitor P16INK4a. Expand
A reappraisal of caloric requirements in healthy women.
TLDR
The metabolism of some lean and obese, nonathletic women was highly efficient, predisposing these women for developing and maintaining body fat and forming a continuum from the lightest to the heaviest woman. Expand
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
  • G. Boden, G. Shulman
  • Biology, Medicine
  • European journal of clinical investigation
  • 1 June 2002
TLDR
Evidence is discussed that FFA represent a crucial link between insulin resistance and β‐cell dysfunction and, as such, a reduction in elevated plasma FFA should be an important therapeutic target in obesity and type 2 diabetes. Expand
Obesity and free fatty acids.
  • G. Boden
  • Medicine
  • Endocrinology and metabolism clinics of North…
  • 1 September 2008
TLDR
The challenges for the future include the prevention or correction of obesity and elevated plasma FFA levels through methods that include decreased caloric intake and increased caloric expenditure, the development of methods to measure FFAs in small blood samples, and the developmentof efficient pharmacologic approaches to normalize increased plasma F FA levels. Expand
Obesity, insulin resistance and free fatty acids
  • G. Boden
  • Medicine
  • Current opinion in endocrinology, diabetes, and…
  • 1 April 2011
TLDR
The role of free fatty acid (FFA) as a cause for insulin resistance in obese people is described and increased plasma FFA levels are an important cause of obesity-associated insulin resistance and cardiovascular disease. Expand
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.
TLDR
It is concluded that FFAs caused hepatic insulin resistance, which can produce overproduction of glucose and hyperglycemia, and initiated inflammatory processes in the liver that could potentially result in the development of steatohepatitis. Expand
Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes
TLDR
The effects of a strict low-carbohydrate diet, which included the diet supplements recommended by Dr. Atkins, on energy intake and expenditure, body weight and body water, glucose metabolism, and insulin sensitivity in obese patients with type 2 diabetes in the controlled environment of a clinical research center are determined. Expand
...
1
2
3
4
5
...