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Development of a physiologically based pharmacokinetic model of 2-methoxyethanol and 2-methoxyacetic acid disposition in pregnant rats.
An accurate description of developing embryos' exposure to a xenobiotic is a desirable component of mechanism-based risk assessments for humans exposed to potential developmental toxicants duringExpand
Toxicokinetics of a single 50 mg/kg oral dose of [2,3-14C]acrylamide in White Leghorn hens.
A single oral dose of [2,3-14C]acrylamide (50 mg/kg) was administered in water to adult white leghorn hens. Seven groups of three hens were euthanized between 2 and 120 hr after administration.Expand
Physiologically based pharmacokinetic models applicable to organogenesis: extrapolation between species and potential use in prenatal toxicity risk assessments.
A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-methoxyacetic acid (2-MAA; the proximate toxicant derived from oxidation of the ethylene glycol ether,Expand
A mathematical model of production, distribution, and metabolism of melatonin in mammalian systems.
Melatonin is a neuroendocrine hormone which is currently receiving considerable attention as a treatment for jet lag, a treatment for insomnia and, by some, a possible "magic bullet" for delaying theExpand
Toxicokinetics of a single 50 mg/kg oral dose of [2,3-14C]acrylamide in White Leghorn hens.
A single oral dose of [2,3-14C]acrylamide (50 mg/kg) was administered in water to adult white leghorn hens. Seven groups of three hens were euthanized between 2 and 120 hr after administration.Expand
Pharmacokinetic profile and placental transfer of a single intravenous injection of [14C]chlorpyrifos in pregnant rats
Abstract. The pharmacokinetics and placental transfer of a single intravenous dose of 5.0 mg/kg (10 µCi/kg) ring-labeled [14C]chlorpyrifos were investigated in pregnant Sprague-Dawley rats at 11–13Expand
Development of a physiologically based pharmacokinetic model to describe the disposition of methanol in pregnant rats and mice.
Physiologically based pharmacokinetic (PBPK) models have been developed in recent years to describe the disposition of xenobiotics during gestation. These models can account for the dynamics ofExpand
Human consumption of methyleugenol and its elimination from serum.
Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxicExpand
Robustness of MetaNet graph models: predicting control of urea production in humans.
Urea production in human liver was described by a MetaNet graph, a flowchart-like representation of metabolic pathways that includes parameters for the kinetic constants of the constituent enzymes.Expand