G. Bisgard

Publications174
h-index33
Citations4,000
Highly Influential Citations97
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  • Publications
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Carotid body mechanisms in acclimatization to hypoxia.
  • G. Bisgard
  • Biology, Medicine
  • Respiration physiology
  • 1 July 2000
Most studies oriented toward examining mechanisms increasing carotid body (CB) sensitivity to hypoxia during ventilatory acclimatization (VAH) have focussed on the role of known neuromodulators of CB… Expand
  • 149
  • 7
Peripheral and central effects of hypoxia
  • 169
  • 5
Ventilatory responses to chemoreceptor stimulation after hypoxic acclimatization in awake goats.
Our objective was to test the hypothesis that exposure to prolonged hypoxia results in altered responsiveness to chemoreceptor stimulation. Acclimatization to hypoxia occurs rapidly in the awake goat… Expand
  • 75
  • 5
Chronic hypoxia‐induced morphological and neurochemical changes in the carotid body
The carotid body (CB) plays an important role in the control of ventilation. Type I cells in CB are considered to be the chemoreceptive element which detects the levels of PO2, PCO2, and [H+] in the… Expand
  • 96
  • 5
Carotid bodies are required for ventilatory acclimatization to chronic hypoxia.
We have compared the ventilatory responses of intact and carotid body-denervated (CBD) goats to moderate [partial pressure of O2 in arterial blood; (Pao2) approximately 44 Torr] and severe (Pao2… Expand
  • 103
  • 4
Recovery of peripheral chemoreceptor function after denervation in ponies.
Resting ventilation (PaCO2) and ventilatory responses to acute hypoxia and to intravenous NaCN were assessed over a 4-yr period following cutting of the carotid sinus nerves and stripping the… Expand
  • 72
  • 4
Ventilatory acclimatization to hypoxia is not dependent on arterial hypoxemia.
Goats were prepared so that one carotid body (CB) could be perfused with blood in which the gas tensions could be controlled independently from the blood perfusing the systemic arterial system,… Expand
  • 81
  • 3
Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia.
Exposing newborn rats to postnatal hyperoxia (60% O2) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our… Expand
  • 70
  • 3
  • PDF
Postnatal growth of the carotid body
  • Z. Wang, G. Bisgard
  • Biology, Medicine
  • Respiratory Physiology & Neurobiology
  • 15 November 2005
The size of the carotid body (CB) is increased significantly during the postnatal period. Type I cells in the CB are the chemoreceptive element and possess many neuron-like characteristics. In… Expand
  • 70
  • 3
Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats.
We have previously reported that broad-spectrum serotonergic blockade increased the acute hypoxic ventilatory response in awake goats. The purpose of the present study was to examine the putative… Expand
  • 15
  • 3