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Carotid body mechanisms in acclimatization to hypoxia.
- G. Bisgard
- Biology, Medicine
- Respiration physiology
- 1 July 2000
Most studies oriented toward examining mechanisms increasing carotid body (CB) sensitivity to hypoxia during ventilatory acclimatization (VAH) have focussed on the role of known neuromodulators of CB… Expand
Ventilatory responses to chemoreceptor stimulation after hypoxic acclimatization in awake goats.
Our objective was to test the hypothesis that exposure to prolonged hypoxia results in altered responsiveness to chemoreceptor stimulation. Acclimatization to hypoxia occurs rapidly in the awake goat… Expand
Chronic hypoxia‐induced morphological and neurochemical changes in the carotid body
The carotid body (CB) plays an important role in the control of ventilation. Type I cells in CB are considered to be the chemoreceptive element which detects the levels of PO2, PCO2, and [H+] in the… Expand
Carotid bodies are required for ventilatory acclimatization to chronic hypoxia.
We have compared the ventilatory responses of intact and carotid body-denervated (CBD) goats to moderate [partial pressure of O2 in arterial blood; (Pao2) approximately 44 Torr] and severe (Pao2… Expand
Recovery of peripheral chemoreceptor function after denervation in ponies.
- G. Bisgard, H. Forster, J. P. Klein
- Chemistry, Medicine
- Journal of applied physiology: respiratory…
- 1 December 1980
Resting ventilation (PaCO2) and ventilatory responses to acute hypoxia and to intravenous NaCN were assessed over a 4-yr period following cutting of the carotid sinus nerves and stripping the… Expand
Ventilatory acclimatization to hypoxia is not dependent on arterial hypoxemia.
Goats were prepared so that one carotid body (CB) could be perfused with blood in which the gas tensions could be controlled independently from the blood perfusing the systemic arterial system,… Expand
Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia.
- G. Bisgard, E. B. Olson, Z-Y Wang, R. W. Bavis, D. Fuller, G. Mitchell
- Biology, Medicine
- Journal of applied physiology
- 1 September 2003
Exposing newborn rats to postnatal hyperoxia (60% O2) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our… Expand
Postnatal growth of the carotid body
The size of the carotid body (CB) is increased significantly during the postnatal period. Type I cells in the CB are the chemoreceptive element and possess many neuron-like characteristics. In… Expand
Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats.
We have previously reported that broad-spectrum serotonergic blockade increased the acute hypoxic ventilatory response in awake goats. The purpose of the present study was to examine the putative… Expand