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Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellularExpand
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Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons
Medium-sized spiny neurons (MSNs) are the only neostriatum projection neurons, and their degeneration underlies some of the clinical features of Huntington’s disease. Using knowledge of humanExpand
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Human Pluripotent Stem Cell Differentiation into Authentic Striatal Projection Neurons
Here we present the principles and steps of a protocol that we have recently developed for the differentiation of hES/iPS cells into the authentic human striatal projection medium spiny neuronsExpand
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Evidence for Spatial Modules Mediated by Temporal Synchronization of Carbachol-Induced Gamma Rhythm in Medial Entorhinal Cortex
Fast (γ) oscillations in the cortex underlie the rapid temporal coordination of large-scale neuronal assemblies in the processing of sensory stimuli. Cortical γ rhythm is modulated in vivo byExpand
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Caveolin-1 expression and membrane cholesterol content modulate N-type calcium channel activity in NG108-15 cells.
Caveolins are the main structural proteins of glycolipid/cholesterol-rich plasmalemmal invaginations, termed caveolae. In addition, caveolin-1 isoform takes part in membrane remodelling as it bindsExpand
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Network activity evoked by neocortical stimulation in area 36 of the guinea pig perirhinal cortex.
The perirhinal cortex is a key structure involved in memory consolidation and retrieval. In spite of the extensive anatomical studies that describe the intrinsic and extrinsic associative connectionsExpand
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Activity-Dependent pH Shifts and Periodic Recurrence of Spontaneous Interictal Spikes in a Model of Focal Epileptogenesis
The mechanisms that control the periodicity of spontaneous epileptiform cortical potentials were investigated in the in vitro isolated guinea pig brain preparation. A brief intracortical applicationExpand
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Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease
In the adult brain, neurons require local cholesterol production, which is supplied by astrocytes through apoE-containing lipoproteins. In Huntington’s disease (HD), such cholesterol biosynthesis inExpand
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Molecular and functional definition of the developing human striatum
  • M. Onorati, Valentina Castiglioni, +14 authors E. Cattaneo
  • Medicine, Biology
  • Nature Neuroscience
  • 1 December 2014
The complexity of the human brain derives from the intricate interplay of molecular instructions during development. Here we systematically investigated gene expression changes in the prenatal humanExpand
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Cytoarchitectonic characterization of the parahippocampal region of the guinea pig
The cytoarchitectonic features of the parahippocampal region (PHR) in the guinea pig are described, based on coronal, horizontal, and sagittal 50‐μm sections stained for Nissl substance, zinc,Expand
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