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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
  • G. Bi, M. Poo
  • Biology, Medicine
  • The Journal of Neuroscience
  • 15 December 1998
In cultures of dissociated rat hippocampal neurons, persistent potentiation and depression of glutamatergic synapses were induced by correlated spiking of presynaptic and postsynaptic neurons. TheExpand
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Synaptic modification by correlated activity: Hebb's postulate revisited.
  • G. Bi, M. Poo
  • Psychology, Medicine
  • Annual review of neuroscience
  • 2001
Correlated spiking of pre- and postsynaptic neurons can result in strengthening or weakening of synapses, depending on the temporal order of spiking. Recent findings indicate that there are narrowExpand
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Stable Hebbian Learning from Spike Timing-Dependent Plasticity
We explore a synaptic plasticity model that incorporates recent findings that potentiation and depression can be induced by precisely timed pairs of synaptic events and postsynaptic spikes. InExpand
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Coactivation and timing-dependent integration of synaptic potentiation and depression
Neuronal synaptic connections can be potentiated or depressed by paired pre- and postsynaptic spikes, depending on the spike timing. We show that in cultured rat hippocampal neurons aExpand
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Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release.
After injury to the cell membrane, rapid resealing of the membrane occurs with little loss of intracellular contents. This process has been studied by measurement of the rate of dye loss afterExpand
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Calcium time course as a signal for spike-timing-dependent plasticity.
Calcium has been proposed as a postsynaptic signal underlying synaptic spike-timing-dependent plasticity (STDP). We examine this hypothesis with computational modeling based on experimental resultsExpand
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CryoEM structure of the mature dengue virus at 3.5-Å resolution
Regulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo–electron microscopy at 3.5-Å resolutionExpand
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Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses
Spike-timing-dependent plasticity (STDP) is considered a physiologically relevant form of Hebbian learning. However, behavioral learning often involves action of reinforcement or reward signals suchExpand
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Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes
Imaging membranes in live cells with nanometer-scale resolution promises to reveal ultrastructural dynamics of organelles that are essential for cellular functions. In this work, we identifiedExpand
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Probing vesicle dynamics in single hippocampal synapses.
We use fluorescence correlation spectroscopy and fluorescence recovery after photobleaching to study vesicle dynamics inside the synapses of cultured hippocampal neurons labeled with the fluorescentExpand
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