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Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis
The results confirm that lesions of the AcbC promote preference for smaller, earlier reinforcers and suggest that this reflects an effect of the lesion on the rate of delay discounting.
Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: A quantitative analysis
Comparison of the effects of 2,5-dimethoxy-4-iodoamphetamine and D-amphetamine on the ability of rats to discriminate the durations and intensities of light stimuli
- C. L. Hampson, S. Body, +6 authors E. Szabadi
- Chemistry, MedicineBehavioural pharmacology
- 1 February 2010
D-Amphetamine and DOI have similar effects on temporal discrimination but different effects on light-intensity discrimination, and the increase in T50 may reflect the impairment of sustained attention during prolonged stimulus presentation.
Evidence for a role of D1 dopamine receptors in d-amphetamine’s effect on timing behaviour in the free-operant psychophysical procedure
The results suggest that d-amphetamine’s effect on performance in the free-operant psychophysical procedure is mediated by D1 rather than D2 receptors, and this effect was antagonised by SKF-83566 but not by haloperidol.
Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors
The results suggest that both 5-HT2A and D1 receptors, but not D2 receptors, are involved in d-amphetamine’s effect on timing behavior in the free-operant psychophysical procedure.
Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: A quantitative analysis
Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors
Stimulation of D1-like dopamine receptors affects performance on the free-operant psychophysical procedure and the interaction between SKF-81297 and a D2-like receptor antagonist haloperidol, were examined.
Evidence that the effect of 5-HT2 receptor stimulation on temporal differentiation is not mediated by receptors in the dorsal striatum
Quantitative analysis of the effect of lesions of the subthalamic nucleus on intertemporal choice: further evidence for enhancement of the incentive value of food reinforcers
- G. Bezzina, T. Cheung, +4 authors E. Szabadi
- Psychology, MedicineBehavioural pharmacology
- 1 September 2009
The STN-lesioned group showed a flatter slope of the indifference function (implying higher instantaneous reinforcer values) than the sham-LESioned group; the intercepts did not differ between the groups.
Effect of quinpirole on timing behaviour in the free-operant psychophysical procedure: evidence for the involvement of D2 dopamine receptors
Results suggest that quinpirole reduced T50 via an action at D2 receptors, suggesting that D1-like and D2-like receptors may mediate behaviourally similar but pharmacologically distinct effects on timing behaviour.