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The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.
- G. Bernard, A. Artigas, +7 authors R. Spragg
- American journal of respiratory and critical care…
- 27 February 1994
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and… Expand
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology,… Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
Objective: To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012.” Design: A consensus committee of 55 international experts representing 25… Expand
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
- J. Marshall, D. Cook, N. Christou, G. Bernard, C. Sprung, W. Sibbald
- Critical care medicine
- 1 October 1995
OBJECTIVE To develop an objective scale to measure the severity of the multiple organ dysfunction syndrome as an outcome in critical illness. DESIGN Systematic literature review; prospective cohort… Expand
Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).
CONTEXT Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a… Expand
Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
ObjectiveTo develop and validate an instrument for use in the intensive care unit to accurately diagnose delirium in critically ill patients who are often nonverbal because of mechanical ventilation.… Expand
Efficacy and safety of recombinant human activated protein C for severe sepsis.
BACKGROUND Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa… Expand
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit.
CONTEXT In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear. OBJECTIVE To determine if delirium… Expand
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS).
CONTEXT Goal-directed delivery of sedative and analgesic medications is recommended as standard care in intensive care units (ICUs) because of the impact these medications have on ventilator weaning… Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
ObjectiveTo provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012”.DesignA consensus committee of 55 international experts representing 25… Expand