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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
&NA; A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated thatExpand
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain. Expand
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
An experimental paclitaxel‐induced painful peripheral neuropathy model is described, which may be useful in understanding a significant source of pain in cancer patients, and in finding ways to avoid the neurotoxicity that limits pac litaxel therapy. Expand
Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET.
Unlike capsaicin-induced pain, allodynia was characterized by bilateral activation of inferior prefrontal cortex, suggesting that prefrontal responses to pain are context dependent. Expand
The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
In addition to identifying a potential drug treatment for painful neuropathy, this study suggests that changes in cannabinoid receptors occurs in nerve injured animals. Expand
Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated, and no differences in mood or quality of life were found. Expand
Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat
The spontaneous discharge and the to K+ channel blockade seen in A beta and A delta primary afferents at the time of the onset of the neuropathic pain syndrome appear to originate in the DRG. Expand
Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction
The data suggest that a paclitaxel‐induced abnormality in axonal mitochondria of sensory nerves contributes topaclitaxe‐induced pain. Expand
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy
It is suggested that mitotoxicity may be the core pathology for all chemotherapy-induced peripheral neuropathy and that drugs that protect mitochondrial function may be useful chemotherapy adjuncts. Expand
Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy
There was a large ipsilateral increase in the density of NPYir axons and varicosities in the lumbar spinal cord on the side of the nerve injury; this was especially apparent in laminae III-V. Expand