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Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice
TLDR
The present study shows the validity of ozonated sesame oil in cutaneous wound healing and emphasizes the importance of the ozonation grade. Expand
Hypoxia induces cell damage via oxidative stress in retinal epithelial cells
TLDR
Investigation of the effects of CoCl2 on human retinal epithelium cells suggests that oxidative stress induced by hypoxia might be involved in RD development through the stimulation of two key-events of RD such as neo-angiogenesis and apoptosis. Expand
Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure.
TLDR
Surprisingly, by transition electron microscopy analysis, it is shown that CAPs were able to penetrate skin tissues, contributing to the understanding of the cutaneous pathophysiological mechanisms initiated by CAPs exposure, where oxidative stress and inflammation may play predominant roles. Expand
NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells.
TLDR
New insight is provided on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonation autohemotherapy, targeted to the restoration of redox homeostasis. Expand
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.
TLDR
The identified inverse co-regulation of Beclin 1 and Mcl-1 represents a mechanism of functional counteraction in cancer. Expand
IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca2+–calmodulin/ERK mitogen-activated protein kinase
TLDR
The NF-kB/Ca(2+)-CaM/ERK signaling pathway is identified as a novel in vivo key regulator of IL-1β-induced astrogliosis which may represent a potential target in neurodegeneration. Expand
Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection
TLDR
Results showed that the mixtures tested were able to protect human keratinocytes from O3-induced cytotoxicity, inhibition of cellular proliferation, decrease the formation of HNE protein adducts, ROS, and carbonyls levels, and observe the decreased activation of the redox sensitive transcription factor NF-kB, which is involved in transcribing pro-inflammatory cytokines. Expand
Scavenger receptor B1 post‐translational modifications in Rett syndrome
TLDR
These findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status. Expand
Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.
TLDR
VA694, Naproxcinod and Naproxen, at both concentrations analyzed, significantly counteracted the negative effects induced by IL-1β, and suggest that these drugs exert anti-inflammatory and chondroprotective effects on OA chondROcytes. Expand
Antiangiogenic VEGF Isoform in Inflammatory Myopathies
TLDR
Findings indicate skeletal muscle expression of antiangiogenic VEGF-A165b and preferential upregulation in IIM, suggesting that modulation of VEGf-A isoforms may occur in myositides. Expand
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