• Publications
  • Influence
Direct reaction of oximes with sarin, soman, or tabun in vitro
The maximal reaction velocities reveal that the detoxification of the nerve agents by direct reaction with oximes and the subsequent decomposition of the phosphonyl oxime in vivo do not substantially contribute to the therapeutic effect of these antidotes. Expand
2-(2-pyridyl-)ethyl esters A new carboxyl protecting group in peptide synthesis
Abstract 2-(2-pyridyl-)ethyl esters are used as chemically inert, highly selective protecting groups that are removable under mild conditions via a two step procedure.
Human metabolism and kinetics of tri-(2-ethylhexyl) trimellitate (TEHTM) after oral administration
This study is the first to elucidateTEHTM metabolism pathways in humans and to identify metabolites of TEHTM in blood and urine by usage of especially designed human biomonitoring methods. Expand
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro
The results obtained with the two sarin analogues indicate that the direct reaction with 2-PAM, obidoxime, or HI 6 could be used for non-corrosive decontamination purposes, especially, if sensitive biological surfaces like skin, mucous membranes, or wounds are considered. Expand
Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase.
The regioselective analysis revealed that the monoester isomers 1-ME HTM and 2-MEHTM were predominantly produced during the degradation of DEHTM isomers, indicating a preferred hydrolysis at the para-position. Expand
Studies on long-acting aryl carboxylic acid esters of testosterone.
A series of aryl carboxylic acid esters of testosterone have been synthesized as possible agents for long-acting steroid therapy and the results show that the partition coefficients increase with increasing chain length and are in keeping with calculated values. Expand
2-(2‘-Pyridyl)-ethyl-ester (Pet ester) derivatives of polyfunctional amino acids
The 2-(2′-pyridyl)-ethyl-esters (Pet-esters) of bi- and tri-functional amino acids are introduced as a semipermanent protecting group in peptide synthesis.