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Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.
CONTEXT Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine. OBJECTIVE To assess the safety and efficacy of folic acidExpand
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The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group.
BACKGROUND Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. We tested these interventions in 840 patients with various chronic renalExpand
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A randomized trial of aspirin to prevent colorectal adenomas.
BACKGROUND Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel. METHODS We performed a randomized, double-blind trial of aspirin as aExpand
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Effect of dialysis dose and membrane flux in maintenance hemodialysis.
BACKGROUND The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain. METHODS WeExpand
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In-center hemodialysis six times per week versus three times per week.
BACKGROUND In this randomized clinical trial, we aimed to determine whether increasing the frequency of in-center hemodialysis would result in beneficial changes in left ventricular mass,Expand
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Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group.
BACKGROUND AND METHODS Laboratory, clinical, and epidemiologic evidence suggests that calcium may help prevent colorectal adenomas. We conducted a randomized, double-blind trial of the effect ofExpand
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The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease
Background Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. We tested these interventions in 840 patients with various chronic renalExpand
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Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score.
OBJECTIVE To relate morbidity and mortality risk to preoperative severity of illness in patients undergoing coronary artery bypass grafting. DESIGN Retrospective analysis of 5051 patients usingExpand
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Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2.
BACKGROUND The Modification of Diet in Renal Disease (MDRD) Study equation underestimates measured glomerular filtration rate (GFR) at levels>60 mL/min/1.73 m2, with variable accuracy amongExpand
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The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial.
Prior small studies have shown multiple benefits of frequent nocturnal hemodialysis compared to conventional three times per week treatments. To study this further, we randomized 87 patients to threeExpand
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