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Opening the blood–brain and blood–tumor barriers in experimental rat brain tumors: The effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow
Using quantitative autoradiography, we investigated the effect of intracarotid infusions of hyperosmolar mannitol solutions on capillary permeability and blood flow. Capillary permeability, expressedExpand
Human brain tumor transplantation into nude mice.
Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice. Compared to experimental animal brain tumors, these tumors, takenExpand
Temporal effects of dexamethasone on blood-to-brain and blood-to-tumor transport of 14C-alpha-aminoisobutyric acid in rat C6 glioma
SummaryWe used quantitative autoradiography (QAR) to evaluate the effect of systemically administered dexamethasone on capillary permeability in brain tumors and surrounding brain. Rats bearingExpand
Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a
Using quantitative autoradiography, we investigated the entry over 90 min of [14C]methotrexate (MTX) into C6 gliomas implanted bilaterally into Wistar rat brains. The [14C]MTX was administered intoExpand
Paclitaxel-induced "recall" soft tissue injury.
Xenograft of Human Malignant Glial Tumors into Brains of Nude Mice A Histopathological Study
Sixteen of 21 human malignant glial tumors were successfully hetero-transplanted into the brains of nude mice, and one other was transplanted into the brain after prior subcutaneousExpand
Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.
1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), a water-soluble nitrosourea, was tested i.v. against three murine gliomas, Ependymoblastoma A, GliomaExpand
In vivo model development of cisplatin-resistant and -sensitive A2780 human ovarian carcinomas.
The human ovarian carcinoma, A2780, and a derived cisplatin-resistant subline, A2780 cDDP, were developed as in vivo sc models in athymic mice. The tumor volume doubling time (TVDT) of both lines wasExpand
Experimental meningeal carcinomatosis selectively depresses local cerebral glucose utilization in rat brain
Using quantitative autoradiography, we investigated the effect of meningeal carcinomatosis on local cerebral glucose utilization (LCGU). A rat model of meningeal carcinomatosis using Walker 256 tumorExpand