Isolation of amniotic stem cell lines with potential for therapy
- P. Coppi, G. Bartsch, A. Atala
- BiologyNature Biotechnology
- 1 May 2007
The isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers are reported and examples of differentiated cells derived from human AFS cells and displaying specialized functions include neuronal lineage cells secreting the neurotransmitter L-glutamate or expressing G-protein-gated inwardly rectifying potassium channels.
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor.
- Z. Culig, A. Hobisch, H. Klocker
- BiologyEuropean Urology
- 15 October 1994
Investigation of effects of growth factors on stimulation of the AR-mediated gene transcription in human prostatic tumor cell lines provides evidence that IGF-I, KGF, and EGF directly activate the AR in the absence of androgens, which means that the androgen-signaling chain may be activated by growth factors in an androgens-depleted environment.
Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
- Z. Culig, J. Hoffmann, H. Klocker
- Biology, MedicineBritish Journal of Cancer
- 1 September 1999
Results show for the first time that the non-steroidal anti-androgen bicalutamide acquires agonistic properties during long-term androgen ablation, which may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention.
Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy…
- R. Kirby, C. Roehrborn, E. Grossman
- MedicineUrology
- 2003
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
- Z. Culig, A. Hobisch, H. Klocker
- Biology, MedicineMolecular Endocrinology
- 1 December 1993
Data demonstrate that the exchange of a single valine into methionine at position 715 in the AR promoters trans-activation not only by testicular but also by adrenal androgens and progesterone may have significance in the process controlling the progression of prostatic carcinoma.
Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production
- C. Rieser, G. Böck, H. Klocker, G. Bartsch, M. Thurnher
- Biology, MedicineJournal of Experimental Medicine
- 3 November 1997
It is demonstrated that P GE2 contributes to the maturation of human DCs and that PGE2 can be a potent enhancer of IL-12 production by human DCe, and most potent in stimulating allogeneic T cell proliferation.
Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.
- A. Hobisch, I. Eder, Z. Culig
- Biology, MedicineCancer Research
- 15 October 1998
It is shown for the first time that IL-6 is a nonsteroidal activator of the AR and that this activation is implicated in the regulation of prostate-specific proteins.
Androgen receptors in prostate cancer.
- Z. Culig, H. Klocker, G. Bartsch, A. Hobisch
- Biology, MedicineEndocrine-Related Cancer
- 1 October 2003
AR function during endocrine therapy was studied in tumor cells LNCaP subjected to long-term steroid depletion; newly generated sublines could be stimulated by lower concentrations of androgen than parental cells and showed up-regulation of AR expression and activity as well as resistance to apoptosis.
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.
- Z. Culig, A. Hobisch, H. Klocker
- BiologyCancer Research
- 1994
Investigation of effects of growth factors on stimulation of the AR-mediated gene transcription in human prostatic tumor cell lines provides evidence that IGF-I, KGF, and EGF directly activate the AR in the absence of androgens, which means that the androgen-signaling chain may be activated by growth factors in an androgens-depleted environment.
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