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Astrocytes: targets for neuroprotection in stroke.
In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in treating stroke, with the exception of thrombolytics. Although many targets have been pursued, includingExpand
Neuroprotection from Stroke in the Absence of MHCI or PirB
Recovery from stroke engages mechanisms of neural plasticity. Here we examine a role for MHC class I (MHCI) H2-Kb and H2-Db, as well as PirB receptor. These molecules restrict synaptic plasticity andExpand
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNSExpand
Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia
Background and Purpose— Stroke causes brain injury with activation of an inflammatory response that can contribute to injury. We tested the hypothesis that the anti-inflammatory cytokineExpand
Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
Previous studies have shown that the neuroprotective hormone, testosterone, administered immediately after neural injury, reduces reactive astrogliosis. In this study we have assessed the effect ofExpand
Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding ofExpand
Astrocyte Proliferation Following Stroke in the Mouse Depends on Distance from the Infarct
Reactive gliosis is a hallmark of brain pathology and the injury response, yet the extent to which astrocytes proliferate, and whether this is central to astrogliosis is still controversial. WeExpand
Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions
In the last years there has been a considerable advance in the knowledge on the regulation of astrocytes by sex steroids under physiological and pathological conditions. By the activation of aExpand
The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway
Benzene is a widespread volatile compound and an environmental contaminant. Since it causes important toxic effects in workers exposed to low levels, long‐term exposure to this compound has beenExpand
Protection after stroke: cellular effectors of neurovascular unit integrity
Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which account for 55% of all neurological diseases, are the leading cause of permanent disability, cognitive and motorExpand