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Mitochondrial Oxygen Radical Generation and Leak: Sites of Production in States 4 and 3, Organ Specificity, and Relation to Aging and Longevity
  • G. Barja
  • Biology, Medicine
  • Journal of bioenergetics and biomembranes
  • 1 August 1999
TLDR
It is agreed that animals with high maximum longevities have low rates of mitochondrial oxygen radical production, irrespective of the value of their basal specific metabolic rate, and their relation to longevity andaging are discussed. Expand
Mitochondrial Free Radical Production and Aging in Mammals and Birds a
  • G. Barja
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 November 1998
TLDR
Heart, brain, and lung mitochondrial ROS production and free radical leak are lower in three species of birds of different orders than in mammals of similar body size and metabolic rate, which suggests that the capacity to show a low rate of ROS production is a general characteristic of birds. Expand
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
  • G. Barja, A. Herrero
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 February 2000
TLDR
The results obtained agree with the notion that oxygen radicals of mitochondrial origin oxidatively damage mtDNA in a way related to the aging rate of each species. Expand
Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
TLDR
The results are consistent with the concept that CR decreases the aging rate at least in part by decreasing the rate of mitochondrial oxygen radical generation and then the rates of attack on mtDNA. Expand
Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals.
TLDR
It may be proposed that, during evolution, a low degree of fatty acid unsaturation in liver mitochondria may have been selected in longevous mammals in order to protect the tissues against oxidative damage, while maintaining an appropriate environment for membrane function. Expand
The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
Abstract The relationship of oxidative stress with maximum life span (MLSP) in different vertebrate species is reviewed. In all animal groups the endogenous levels of enzymatic and non-enzymaticExpand
Minireview: The Quantitative Measurement of H2O2 Generation in Isolated Mitochondria
  • G. Barja
  • Chemistry, Medicine
  • Journal of bioenergetics and biomembranes
  • 1 June 2002
TLDR
A fluorometric method appropriate to measure the rate of generation of H2O2 in intact mitochondria and its application to the localization of the sites where caloric restriction decreases mitochondrial oxygen radical generation in heart mitochondria is described. Expand
Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?
  • G. Barja
  • Biology, Medicine
  • Biological reviews of the Cambridge Philosophical…
  • 1 May 2004
TLDR
It is suggested that a low rate of mitochondrial ROS generation extends lifespan both in long‐lived and in caloric‐restricted animals by determining the rate of oxidative attack and accumulation of somatic mutations in mitochondrial DNA. Expand
Free radicals and aging
  • G. Barja
  • Biology, Medicine
  • Trends in Neurosciences
  • 1 October 2004
TLDR
Caloric restriction, which decreases the rate of aging, proportionately decreases mitochondrial oxygen radical generation, especially at complex I, and the results obtained in the brain are reviewed. Expand
Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon
TLDR
The results indicate that Complexes I and III are the main H 2O2 generators of heart mitochondria in rats and pigeons and that both Complexes are responsible for the low H2O2 production of the bird. Expand
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