Mitochondrial Oxygen Radical Generation and Leak: Sites of Production in States 4 and 3, Organ Specificity, and Relation to Aging and Longevity
- G. Barja
- BiologyJournal of Bioenergetics and Biomembranes
- 1 August 1999
It is agreed that animals with high maximum longevities have low rates of mitochondrial oxygen radical production, irrespective of the value of their basal specific metabolic rate, and their relation to longevity andaging are discussed.
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
- G. Barja, A. Herrero
- BiologyThe FASEB Journal
- 1 February 2000
The results obtained agree with the notion that oxygen radicals of mitochondrial origin oxidatively damage mtDNA in a way related to the aging rate of each species.
Mitochondrial Free Radical Production and Aging in Mammals and Birds a
- G. Barja
- BiologyAnnals of the New York Academy of Sciences
- 1 November 1998
Heart, brain, and lung mitochondrial ROS production and free radical leak are lower in three species of birds of different orders than in mammals of similar body size and metabolic rate, which suggests that the capacity to show a low rate of ROS production is a general characteristic of birds.
Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
- R. Gredilla, A. Sanz, M. López-Torres, G. Barja
- BiologyThe FASEB Journal
- 1 July 2001
The results are consistent with the concept that CR decreases the aging rate at least in part by decreasing the rate of mitochondrial oxygen radical generation and then the rates of attack on mtDNA.
Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals.
- R. Pamplona, M. Portero-Otín, G. Barja
- BiologyJournal of Lipid Research
- 1 October 1998
The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
- R. Pérez-Campo, M. López-Torres, S. Cadenas, C. Rojas, G. Barja
- BiologyJournal of Comparative Physiology □ B
- 1 April 1998
Abstract The relationship of oxidative stress with maximum life span (MLSP) in different vertebrate species is reviewed. In all animal groups the endogenous levels of enzymatic and non-enzymatic…
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.
- R. Pamplona, G. Barja
- BiologyBiochimica et Biophysica Acta
- 1 May 2006
Rate of generation of oxidative stress-related damage and animal longevity.
- G. Barja
- BiologyFree Radical Biology & Medicine
- 1 November 2002
Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts.
- G. Barja
- BiologyAntioxidants and Redox Signaling
- 4 October 2013
An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity is reviewed and two general characteristics responsible for the high maintenance degree of long-lived animals emerge: a low generation rate of endogenous damage and the possession of tissue macromolecules that are highly resistant to oxidative modification.
Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?
- G. Barja
- BiologyBiological Reviews of The Cambridge Philosophical…
- 1 May 2004
It is suggested that a low rate of mitochondrial ROS generation extends lifespan both in long‐lived and in caloric‐restricted animals by determining the rate of oxidative attack and accumulation of somatic mutations in mitochondrial DNA.
...
...