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High carrier frequency of the 35delG deafness mutation in European populations
Congenital deafness accounts for about 1 in 1000 infants and approximately 80% of cases are inherited as an autosomal recessive trait. Recently, it has been demonstrated that connexin 26 (GJB2) geneExpand
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Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language.
Clinal patterns of autosomal genetic diversity within Europe have been interpreted in previous studies in terms of a Neolithic demic diffusion model for the spread of agriculture; in contrast,Expand
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An apportionment of human DNA diversity.
It is often taken for granted that the human species is divided in rather homogeneous groups or races, among which biological differences are large. Studies of allele frequencies do not support thisExpand
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CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
Background and objective CYP2D6, a member of the cytochrome P450 superfamily, is responsible for the metabolism of about 25% of the commonly prescribed drugs. Its activity ranges from completeExpand
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Geographic patterns of mtDNA diversity in Europe.
Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic ( approximately 45,000 years before the present [BP]), Mesolithic ( approximately 18,000Expand
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The origin of European cattle: evidence from modern and ancient DNA.
Cattle domestication from wild aurochsen was among the most important innovations during the Neolithic agricultural revolution. The available genetic and archaeological evidence points to at leastExpand
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Tracing past human male movements in northern/eastern Africa and western Eurasia: new clues from Y-chromosomal haplogroups E-M78 and J-M12.
Detailed population data were obtained on the distribution of novel biallelic markers that finely dissect the human Y-chromosome haplogroup E-M78. Among 6,501 Y chromosomes sampled in 81 humanExpand
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A Predominantly Neolithic Origin for European Paternal Lineages
Most present-day European men inherited their Y chromosomes from the farmers who spread from the Near East 10,000 years ago, rather than from the hunter-gatherers of the Paleolithic.
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Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans
During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregionalExpand
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Zones of sharp genetic change in Europe are also linguistic boundaries.
  • G. Barbujani, R. Sokal
  • Biology, Geography
  • Proceedings of the National Academy of Sciences…
  • 1 March 1990
A newly elaborated method, "Wombling," for detecting regions of abrupt change in biological variables was applied to 63 human allele frequencies in Europe. Of the 33 gene-frequency boundariesExpand
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