STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- Hiroki Ishikawa, Zhe Ma, G. Barber
- 8 October 2009
It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- Hiroki Ishikawa, G. Barber
- 13 November 2008
This corrects the article to show that the H2O2/H2O/O2 mixture is dominated by the H3O/ O2 mixture, rather than the O2/O3 mixture, which is more commonly associated with H2Os.
Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
- N. Grandvaux, M. Servant, J. Hiscott
- BiologyJournal of Virology
- 1 June 2002
Results demonstrate that, in addition to its role in the formation of a functional immediate-early IFN-β enhanceosome, IRF-3 is able to discriminate among ISRE-containing genes involved in the establishment of the antiviral state as a direct response to virus infection.
STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling
- Hiroki Ishikawa, G. Barber
- 24 August 2008
The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
- Seng-Ryong Woo, M. Fuertes, T. Gajewski
- Biology, MedicineImmunity
- 20 November 2014
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.
- D. R. Taylor, S. Shi, P. Romano, G. Barber, M. Lai
- Biology, MedicineScience
- 2 July 1999
It is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2alpha, a target of PKR.
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
STING: infection, inflammation and cancer
- G. Barber
- BiologyNature reviews. Immunology
- 25 November 2015
The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.
Cytoplasmic chromatin triggers inflammation in senescence and cancer
- Zhixun Dou, Kanad Ghosh, S. Berger
- 4 October 2017
It is shown that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING (cyclic GMP–AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.
Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
STING has been identified as a critical signaling molecule required for the detection of cytosolic dsDNAs derived from pathogens and viruses and TBK1 is established as a downstream kinase controlling dsDNA-mediated IRF3 and NF-κB signaling dependent on STING.